Lab-on-a-chip with integrated optical transducers

被引:166
作者
Balslev, S [1 ]
Jorgensen, AM [1 ]
Bilenberg, B [1 ]
Mogensen, KB [1 ]
Snakenborg, D [1 ]
Geschke, O [1 ]
Kutter, JP [1 ]
Kristensen, A [1 ]
机构
[1] Tech Univ Denmark, MIC Dept Micro & Nanotechnol, DK-2800 Kongens Lyngby, Denmark
关键词
D O I
10.1039/b512546d
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Taking the next step from individual functional components to higher integrated devices, we present a feasibility study of a lab-on-a-chip system with five different components monolithically integrated on one substrate. These five components represent three main domains of microchip technology: optics, fluidics and electronics. In particular, this device includes an on-chip optically pumped liquid dye laser, waveguides and fluidic channels with passive diffusive mixers, all defined in one layer of SU-8 polymer, as well as embedded photodiodes in the silicon substrate. The dye laser emits light at 576 nm, which is directly coupled into five waveguides that bring the light to five different locations along a fluidic channel for absorbance measurements. The transmitted portion of the light is collected at the other side of this cuvette, again by waveguides, and finally detected by the photodiodes. Electrical read-out is accomplished by integrated metal connectors. To our knowledge, this is the first time that integration of all these components has been demonstrated.
引用
收藏
页码:213 / 217
页数:5
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