MAPU 2.0: high-accuracy proteomes mapped to genomes

被引：15

作者：

Gnad, Florian ^{[1
]}

Oroshi, Mario ^{[1
]}

Birney, Ewan ^{[2
]}

Mann, Matthias ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Prote & Signal Transduct, D-82152 Martinsried, Germany

[2] European Bioinformat Inst EMBL EBI, Cambridge CB10 1SD, England

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

关键词：

PROTEIN; DATABASE; IDENTIFICATIONS; PEPTIDEATLAS; PRIDE;

D O I：

10.1093/nar/gkn773

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The MAPU 2.0 database contains proteomes of organelles, tissues and cell types measured by mass spectrometry ( MS)-based proteomics. In contrast to other databases it is meant to contain a limited number of experiments and only those with very high-resolution and -accuracy data. MAPU 2.0 displays the proteomes of organelles, tissues and body fluids or conversely displays the occurrence of proteins of interest in all these proteomes. The new release addresses MS-specific problems including ambiguous peptide-to-protein assignments and it provides insight into general functional features on the protein level ranging from gene ontology classification to comprehensive SwissProt annotation. Moreover, the derived proteomic data are used to annotate the genomes using Distributed Annotation Service (DAS) via EnsEMBL services. MAPU 2.0 is a model for a database specifically designed for high-accuracy proteomics and a member of the ProteomExchange Consortium. It is available on line at http://www.mapuproteome.com.

引用

页码：D902 / D906

页数：5

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