Serotonin syndrome in a child associated with erythromycin and sertraline

被引:24
作者
Lee, DO
Lee, CD
机构
[1] Emory Univ, Sch Med, Dept Psychiat, Div Child & Adolescent Psychiat, Atlanta, GA 30322 USA
[2] United Pharm Serv, Lilburn, GA 30247 USA
来源
PHARMACOTHERAPY | 1999年 / 19卷 / 07期
关键词
D O I
10.1592/phco.19.10.894.31561
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Serotonin syndrome is an uncommon, serious adverse reaction that is usually associated with the interaction of two or more serotonergic agents. A 12-year-old boy receiving sertraline developed the syndrome after erythromycin was added to his regimen. The proposed mechanism involves erythromycin inactivation of cytochrome P450 3A4 inhibition of sertraline metabolism, accumulation of the drug, and precipitation of the syndrome. It is important for clinicians to consider both pharmacokinetic and pharmacodynamic interactions to minimize the risk of the reaction.
引用
收藏
页码:894 / 896
页数:3
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