Cyto-mechanoresponsive Polyelectrolyte Multilayer Films

被引：27

作者：

Davila, Johanna ^{[2
]}

Chassepot, Armelle ^{[3
,4
]}

Longo, Johan ^{[2
]}

Boulmedais, Fouzia ^{[1
,2
]}

Reisch, Andreas ^{[5
]}

Frisch, Benoit ^{[1
,5
]}

Meyer, Florent ^{[3
,4
]}

Voegel, Jean-Claude ^{[3
,4
]}

Mesini, Philippe J. ^{[2
]}

Senger, Bernard ^{[3
,4
]}

Metz-Boutigue, Marie-Helene ^{[3
,4
]}

Hemmerle, Joseph ^{[3
,4
]}

Lavalle, Philippe ^{[3
,4
]}

Schaaf, Pierre ^{[1
]}

Jierry, Loic ^{[1
,2
]}

机构：

[1] Int Ctr Frontier Res Chem, F-67083 Strasbourg, France

[2] Inst Charles Sadron, CNRS, UPR 22, F-67034 Strasbourg, France

[3] Inst Natl Sante & Rech Med, INSERM, Unite 977, F-67085 Strasbourg, France

[4] Univ Strasbourg, Fac Chirurg Dent, F-67000 Strasbourg, France

[5] Univ Strasbourg, CNRS, Lab Concept & Applicat Mol Bioact, UMR 7199, F-67401 Illkirch Graffenstaden, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 01期

关键词：

FORCE; MECHANOTRANSDUCTION; ACTIVATION; BONDS;

D O I：

10.1021/ja208970b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cell adhesion processes take place through mechanotransduction mechanisms where stretching of proteins results in biological responses. In this work, we present the first cyto-mechanoresponsive surface that mimics such behavior by becoming cell-adhesive through exhibition of arginine glycine aspartic acid (RGD) adhesion peptides under stretching. This mechanoresponsive surface is based on polyelectrolyte multilayer films built on a silicone sheet and where RGD-grafted polyelectrolytes are embedded under antifouling phosphorylcholine-grafted polyelectrolytes. The stretching of this film induces an increase in fibroblast cell viability and adhesion.

引用

页码：83 / 86

页数：4

共 16 条

[1] Mechanically-Induced Chemical Changes in Polymeric Materials [J].

Caruso, Mary M. ;

Davis, Douglas A. ;

Shen, Qilong ;

Odom, Susan A. ;

Sottos, Nancy R. ;

White, Scott R. ;

Moore, Jeffrey S. .

CHEMICAL REVIEWS, 2009, 109 (11) :5755-5798

[2] Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: Insights into nonfouling properties of zwitterionic materials [J].

Chen, SF ;

Zheng, J ;

Li, LY ;

Jiang, SY .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (41) :14473-14478

[3] Force-induced activation of covalent bonds in mechanoresponsive polymeric materials [J].

Davis, Douglas A. ;

Hamilton, Andrew ;

Yang, Jinglei ;

Cremar, Lee D. ;

Van Gough, Dara ;

Potisek, Stephanie L. ;

Ong, Mitchell T. ;

Braun, Paul V. ;

Martinez, Todd J. ;

White, Scott R. ;

Moore, Jeffrey S. ;

Sottos, Nancy R. .

NATURE, 2009, 459 (7243) :68-72

[4] Fuzzy nanoassemblies: Toward layered polymeric multicomposites [J].

Decher, G .

SCIENCE, 1997, 277 (5330) :1232-1237

[5] Balancing forces: architectural control of mechanotransduction [J].

DuFort, Christopher C. ;

Paszek, Matthew J. ;

Weaver, Valerie M. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2011, 12 (05) :308-319

[6] Changes of the Molecular Structure in Polyelectrolyte Multilayers under Stress [J].

Frueh, Johannes ;

Koehler, Ralf ;

Moehwald, Helmuth ;

Krastev, Rumen .

LANGMUIR, 2010, 26 (19) :15516-15522

[7] Form and function in multilayer assembly: New applications at the nanoscale [J].

Hammond, PT .

ADVANCED MATERIALS, 2004, 16 (15) :1271-1293

[8] Multilayered polyelectrolyte films: a tool for arteries and vessel repair [J].

Kerdjoudj, Halima ;

Berthelemy, Nicolas ;

Boulmedais, Fouzia ;

Stoltz, Jean-Francois ;

Menu, Patrick ;

Voegel, Jean Claude .

SOFT MATTER, 2010, 6 (16) :3722-3734

[9] Cell Response to RGD Density in Cross-Linked Artificial Extracellular Matrix Protein Films [J].

Liu, Julie C. ;

Tirrell, David A. .

BIOMACROMOLECULES, 2008, 9 (11) :2984-2988

[10] Energy landscapes of receptor-ligand bonds explored with dynamic force spectroscopy [J].

Merkel, R ;

Nassoy, P ;

Leung, A ;

Ritchie, K ;

Evans, E .

NATURE, 1999, 397 (6714) :50-53

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