Cyto-mechanoresponsive Polyelectrolyte Multilayer Films

被引：28

作者：

Davila, Johanna ^{[2
]}

Chassepot, Armelle ^{[3
,4
]}

Longo, Johan ^{[2
]}

Boulmedais, Fouzia ^{[1
,2
]}

Reisch, Andreas ^{[5
]}

Frisch, Benoit ^{[1
,5
]}

Meyer, Florent ^{[3
,4
]}

Voegel, Jean-Claude ^{[3
,4
]}

Mesini, Philippe J. ^{[2
]}

Senger, Bernard ^{[3
,4
]}

Metz-Boutigue, Marie-Helene ^{[3
,4
]}

Hemmerle, Joseph ^{[3
,4
]}

Lavalle, Philippe ^{[3
,4
]}

Schaaf, Pierre ^{[1
]}

Jierry, Loic ^{[1
,2
]}

机构：

[1] Int Ctr Frontier Res Chem, F-67083 Strasbourg, France

[2] Inst Charles Sadron, CNRS, UPR 22, F-67034 Strasbourg, France

[3] Inst Natl Sante & Rech Med, INSERM, Unite 977, F-67085 Strasbourg, France

[4] Univ Strasbourg, Fac Chirurg Dent, F-67000 Strasbourg, France

[5] Univ Strasbourg, CNRS, Lab Concept & Applicat Mol Bioact, UMR 7199, F-67401 Illkirch Graffenstaden, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 01期

关键词：

FORCE; MECHANOTRANSDUCTION; ACTIVATION; BONDS;

D O I：

10.1021/ja208970b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cell adhesion processes take place through mechanotransduction mechanisms where stretching of proteins results in biological responses. In this work, we present the first cyto-mechanoresponsive surface that mimics such behavior by becoming cell-adhesive through exhibition of arginine glycine aspartic acid (RGD) adhesion peptides under stretching. This mechanoresponsive surface is based on polyelectrolyte multilayer films built on a silicone sheet and where RGD-grafted polyelectrolytes are embedded under antifouling phosphorylcholine-grafted polyelectrolytes. The stretching of this film induces an increase in fibroblast cell viability and adhesion.

引用

页码：83 / 86

页数：4

共 16 条

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