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Suppression of collagen-induced arthritis by oral administration of the citrus flavonoid hesperidin

被引：62
作者：
Kawaguchi, K
Maruyama, H
Kometani, T
Kumazawa, Y
机构：
[1] Kitasato Univ, Sch Sci, Dept Biosci, Sagamihara, Kanagawa 2288555, Japan
[2] Kitasato Univ, Sch Pharmaceut Sci, Sagamihara, Kanagawa 228, Japan
[3] Kitasato Univ, Sch Allied Hlth Sci, Dept Pathol, Sagamihara, Kanagawa 228, Japan
[4] Ezaki Glico Co Ltd, Cent Res Lab, Osaka, Japan
[5] Kitasato Univ, Grad Sch Fundamental Life Sci, Sagamihara, Kanagawa 228, Japan
来源：
PLANTA MEDICA | 2006年 / 72卷 / 05期
关键词：
D O I：
10.1055/s-2005-916254
中图分类号：
Q94 [植物学];
学科分类号：
071001 [植物学];
摘要：
The preventive and therapeutic effects of the Citrus flavonoid hesperidin (HES) on the development of collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA), were investigated. Mice were administered orally HES three times a week starting from either the onset (day 21) of secondary immunization or on day 31, when the CIA development had reached a plateau. In both cases, treatment with HES resulted in a significant suppression of clinical scores and improvement of histological features. These results suggest that oral administration of HES could be effective for treating human RA patients.
引用
收藏
页码：477 / 479
页数：3
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