Enantioselective total synthesis of (+)-SCH 351448

被引：20

作者：

Crimmins, Michael T. ^{[1
]}

Vanier, Grace S. ^{[1
]}

机构：

[1] Univ N Carolina, Venable & Kenan Labs Chem, Chapel Hill, NC 27599 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 13期

关键词：

D O I：

10.1021/ol061073b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective synthesis of SCH 351448 has been completed. Twelve of the fourteen stereogenic centers were established through chiral enolate reactions, and six key C-C bonds were formed by metathesis reactions.

引用

页码：2887 / 2890

页数：4

共 15 条

[11] Total synthesis of (+)-SCH 351448 [J].

Kang, EJ ;

Cho, EJ ;

Lee, YE ;

Ji, MK ;

Shin, DM ;

Chung, YK ;

Lee, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (09) :2680-2681

[12] OXIDATION OF LONG-CHAIN AND RELATED ALCOHOLS TO CARBONYLS BY DIMETHYL-SULFOXIDE ACTIVATED BY OXALYL CHLORIDE [J].

MANCUSO, AJ ;

HUANG, SL ;

SWERN, D .

JOURNAL OF ORGANIC CHEMISTRY, 1978, 43 (12) :2480-2482

[13] Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligands [J].

Scholl, M ;

Ding, S ;

Lee, CW ;

Grubbs, RH .

ORGANIC LETTERS, 1999, 1 (06) :953-956

[14]

SEEBACH D, 1985, ORG SYNTH, V63, P109

[15] A concise synthesis of (+)-SCH 351448 [J].

Soltani, O ;

De Brabander, JK .

ORGANIC LETTERS, 2005, 7 (13) :2791-2793

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