A concise synthesis of (+)-SCH 351448

被引：30

作者：

Soltani, O ^{[1
]}

De Brabander, JK ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 13期

关键词：

D O I：

10.1021/ol0510769

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

yWe describe a highly convergent synthetic approach to the natural product (+)-SCH 351448 (1)-a hexane-soluble heptacoordinate monosodium salt of a C-2-symmetrical macrocyclic dilactone. Our approach implements a photochemical acylation as the key step to combine two nearly identical but orthogonal C1-C29 fragments, followed by a base-induced intramolecular acylation and deprotection to yield the natural product.

引用

页码：2791 / 2793

页数：3

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