Pathogenic Pore-Forming Proteins: Function and Host Response

被引：146

作者：

Bischofberger, Mirko ^{[1
]}

Iacovache, Ioan ^{[1
]}

van der Goot, F. Gisou ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Global Hlth Inst, CH-1015 Lausanne, Switzerland

来源：

CELL HOST & MICROBE | 2012年 / 12卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

PLASMA-MEMBRANE-REPAIR; AUREUS ALPHA-TOXIN; CHOLESTEROL-DEPENDENT CYTOLYSIN; NF-KAPPA-B; LISTERIOLYSIN-O; CASPASE-1; ACTIVATION; CELL-DEATH; NLRP3; INFLAMMASOME; HEMOLYSIN; DISRUPTION;

D O I：

10.1016/j.chom.2012.08.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Organisms from all kingdoms produce pore-forming proteins, with the best-characterized being of bacterial origin. The last decade of research has revealed that the channels formed by these proteins can be very diverse, thus differentially affecting target cell-membrane permeability and consequent cellular outcome. The responses to these toxins are also extremely diverse due to multiple downstream effects of pore-induced changes in ion balance. Determining the secondary effects of pore-forming toxins is essential to understand their contribution to infection.

引用

页码：266 / 275

页数：10

共 116 条

[21] Cell Membranes: The Lipid Perspective [J].

Coskun, Uenal ;

Simons, Kai .

STRUCTURE, 2011, 19 (11) :1543-1548

[22] Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells [J].

Craven, Robin R. ;

Gao, Xi ;

Allen, Irving C. ;

Gris, Denis ;

Wardenburg, Juliane Bubeck ;

McElvania-TeKippe, Erin ;

Ting, Jenny P. ;

Duncan, Joseph A. .

PLOS ONE, 2009, 4 (10)

[23] The UPEC Pore-Forming Toxin α-Hemolysin Triggers Proteolysis of Host Proteins to Disrupt Cell Adhesion, Inflammatory, and Survival Pathways [J].

Dhakal, Bijaya K. ;

Mulvey, Matthew A. .

CELL HOST & MICROBE, 2012, 11 (01) :58-69

[24] Subcytocidal attack by staphylococcal alpha-toxin activates NF-κB and induces interleukin-8 production [J].

Dragneva, Y ;

Anuradha, CD ;

Valeva, A ;

Hoffmann, A ;

Bhakdi, S ;

Husmann, M .

INFECTION AND IMMUNITY, 2001, 69 (04) :2630-2635

[25] C. elegans Detects Pathogen-Induced Translational Inhibition to Activate Immune Signaling [J].

Dunbar, Tiffany L. ;

Yan, Zhi ;

Balla, Keir M. ;

Smelkinson, Margery G. ;

Troemel, Emily R. .

CELL HOST & MICROBE, 2012, 11 (04) :375-386

[26] Inflammasome Activation by Adenylate Cyclase Toxin Directs Th17 Responses and Protection against Bordetella pertussis [J].

Dunne, Aisling ;

Ross, Padraig J. ;

Pospisilova, Eva ;

Masin, Jiri ;

Meaney, Aoife ;

Sutton, Caroline E. ;

Iwakura, Yoichiro ;

Tschopp, Jurg ;

Sebo, Peter ;

Mills, Kingston H. G. .

JOURNAL OF IMMUNOLOGY, 2010, 185 (03) :1711-1719

[27] Staphylococcus aureus α-toxin-induced cell death:: predominant necrosis despite apoptotic caspase activation [J].

Essmann, F ;

Bantel, H ;

Totzke, G ;

Engels, IH ;

Sinha, B ;

Schulze-Osthoff, K ;

Jänicke, RU .

CELL DEATH AND DIFFERENTIATION, 2003, 10 (11) :1260-1272

[28] Calcium Influx Rescues Adenylate Cyclase-Hemolysin from Rapid Cell Membrane Removal and Enables Phagocyte Permeabilization by Toxin Pores [J].

Fiser, Radovan ;

Masin, Jiri ;

Bumba, Ladislav ;

Pospisilova, Eva ;

Fayolle, Catherine ;

Basler, Marek ;

Sadilkova, Lenka ;

Adkins, Irena ;

Kamanova, Jana ;

Cerny, Jan ;

Konopasek, Ivo ;

Osicka, Radim ;

Leclerc, Claude ;

Sebo, Peter .

PLOS PATHOGENS, 2012, 8 (04)

[29] Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila [J].

Fontana, Mary F. ;

Banga, Simran ;

Barry, Kevin C. ;

Shen, Xihui ;

Tan, Yunhao ;

Luo, Zhao-Qing ;

Vance, Russell E. .

PLOS PATHOGENS, 2011, 7 (02)

[30] Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein [J].

Fujita, K ;

Katahira, J ;

Horiguchi, Y ;

Sonoda, N ;

Furuse, M ;

Tsukita, S .

FEBS LETTERS, 2000, 476 (03) :258-261

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