Protein folding in a force clamp

被引：11

作者：

Cieplak, Marek

Szymczak, P.

机构：

[1] Polish Acad Sci, Inst Phys, PL-02668 Warsaw, Poland

[2] Univ Warsaw, Inst Theoret Phys, PL-00681 Warsaw, Poland

来源：

JOURNAL OF CHEMICAL PHYSICS | 2006年 / 124卷 / 19期

关键词：

D O I：

10.1063/1.2192768

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Kinetics of folding of a protein held in a force clamp are compared to an unconstrained folding. The comparison is made within a simple topology-based dynamical model of ubiquitin. We demonstrate that the experimentally observed variations in the end-to-end distance reflect microscopic events during folding. However, the folding scenarios in and out of the force clamp are distinct. (c) 2006 American Institute of Physics.

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页数：4

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共 29 条

[11] Force-clamp spectroscopy monitors the folding trajectory of a single protein [J].

Fernandez, JM ;

Li, HB .

SCIENCE, 2004, 303 (5664) :1674-1678

[12] Molecular dynamics of folding of secondary structures in Go-type models of proteins [J].

Hoang, TX ;

Cieplak, M .

JOURNAL OF CHEMICAL PHYSICS, 2000, 112 (15) :6851-6862

[13] Sequencing of folding events in Go-type proteins [J].

Hoang, TX ;

Cieplak, M .

JOURNAL OF CHEMICAL PHYSICS, 2000, 113 (18) :8319-8328

[14] PROTEIN-FOLDING DYNAMICS [J].

KARPLUS, M ;

WEAVER, DL .

NATURE, 1976, 260 (5550) :404-406

[15] Distinguishing between two-state and three-state models for ubiquitin folding [J].

Krantz, BA ;

Sosnick, TR .

BIOCHEMISTRY, 2000, 39 (38) :11696-11701

[16] Diffusion dynamics, moments, and distribution of first-passage time on the protein-folding energy landscape, with applications to single molecules [J].

Lee, CL ;

Lin, CT ;

Stell, G ;

Wang, J .

PHYSICAL REVIEW E, 2003, 67 (04) :5

[17] Multiple stepwise refolding of immunoglobulin domain I27 upon force quench depends on initial conditions [J].

Li, MS ;

Hu, CK ;

Klimov, DK ;

Thirumalai, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (01) :93-98

[18] Simulation of the mechanical unfolding of ubiquitin: Probing different unfolding reaction coordinates by changing the pulling geometry [J].

Li, PC ;

Makarov, DE .

JOURNAL OF CHEMICAL PHYSICS, 2004, 121 (10) :4826-4832

[19] Stepwise unfolding of titin under force-clamp atomic force microscopy [J].

Oberhauser, AF ;

Hansma, PK ;

Carrion-Vazquez, M ;

Fernandez, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (02) :468-472

[20] The unfolding kinetics of ubiquitin captured with single-molecule force-clamp techniques [J].

Schlierf, M ;

Li, HB ;

Fernandez, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (19) :7299-7304