A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes

被引：26

作者：

Chamorro, Cristina ^{[1
]}

Kruijtzer, John A. W. ^{[1
]}

Farsaraki, Marina ^{[1
]}

Balzarini, Jan ^{[2
]}

Liskamp, Rob M. J. ^{[1
]}

机构：

[1] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Fac Sci, NL-3508 TB Utrecht, Netherlands

[2] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 07期

关键词：

CARBOXYL PROTECTING GROUP; STRATEGY; RECEPTOR; DESIGN; GP120; ACIDS;

D O I：

10.1039/b817357e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this Communication, the access to three different peptide loops attached to a small triazacyclophane (TAC) scaffold molecule for the mimicry of discontinuous epitopes present in, for example, antibodies is described for the first time.

引用

页码：821 / 823

页数：3

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