Pharmacogenomics Knowledge for Personalized Medicine

被引：1381

作者：

Whirl-Carrillo, M. ^{[1
]}

McDonagh, E. M. ^{[1
]}

Hebert, J. M. ^{[1
]}

Gong, L. ^{[1
]}

Sangkuhl, K. ^{[1
]}

Thorn, C. F. ^{[1
]}

Altman, R. B. ^{[1
,2
,3
]}

Klein, T. E. ^{[1
]}

机构：

[1] Stanford Univ, Dept Genet, Palo Alto, CA 94304 USA

[2] Stanford Univ, Dept Bioengn, Palo Alto, CA 94304 USA

[3] Stanford Univ, Dept Med, Palo Alto, CA 94304 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2012年 / 92卷 / 04期

关键词：

D O I：

10.1038/clpt.2012.96

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The Pharmacogenomics Knowledgebase (PharmGKB) is a resource that collects, curates, and disseminates information about the impact of human genetic variation on drug responses. It provides clinically relevant information, including dosing guidelines, annotated drug labels, and potentially actionable gene-drug associations and genotype-phenotype relationships. Curators assign levels of evidence to variant-drug associations using well-defined criteria based on careful literature review. Thus, PharmGKB is a useful source of high-quality information supporting personalized medicine-implementation projects.

引用

页码：414 / 417

页数：4

共 4 条

[1]

Implementing Personalized Medicine: Development of a Cost-Effective Customized Pharmacogenetics Genotyping Array [J].