Targeting Epigenetic Readers in Cancer

被引：300

作者：

Dawson, Mark A. ^{[1
,2
,3
,4
]}

Kouzarides, Tony ^{[3
,4
]}

Huntly, Brian J. P. ^{[1
,2
,5
]}

机构：

[1] Univ Cambridge, Dept Haematol, Cambridge Inst Med Res, Cambridge CB2 0XY, England

[2] Univ Cambridge, Cambridge Univ Hosp Natl Hlth Serv Fdn Trust, Cambridge CB2 0XY, England

[3] Univ Cambridge, Gurdon Inst, Cambridge CB2 0XY, England

[4] Univ Cambridge, Dept Pathol, Cambridge CB2 0XY, England

[5] Univ Cambridge, Wellcome Trust & Med Res Council, Cambridge Stem Cell Inst, Cambridge CB2 0XY, England

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2012年 / 367卷 / 07期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

BROMODOMAIN PROTEIN BRD4; FRAGMENT-BASED DISCOVERY; ACUTE MYELOID-LEUKEMIA; HISTONE H3; TRANSCRIPTIONAL REGULATION; CHROMATIN MODIFICATIONS; MOLECULAR-MECHANISM; MULTIPLE-MYELOMA; DRUG-SENSITIVITY; BET BROMODOMAINS;

D O I：

10.1056/NEJMra1112635

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：647 / 657

页数：11

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