Integrated approach to the multidimensional analysis of complex biological samples by microseparation techniques - Analysis of glycoprotein factor associated with cancer cachexia

被引：13

作者：

Choudhary, G

Hancock, W

Witt, K

Rozing, G

Torres-Duarte, A

Wainer, I

机构：

[1] Hewlett Packard Labs, Biomeasurements Grp, Palo Alto, CA 94304 USA

[2] Hewlett Packard GMBH, Waldbronn Analyt Div, Waldbronn, Germany

[3] Georgetown Univ, Med Ctr, Dept Pharmacol, Washington, DC 20007 USA

来源：

JOURNAL OF CHROMATOGRAPHY A | 1999年 / 857卷 / 1-2期

关键词：

instrumentation; multidimensional separation; glycoproteins; proteins;

D O I：

10.1016/S0021-9673(99)00783-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Microanalytical separation techniques including capillary liquid chromatography, capillary electrophoresis and capillary electrochromatography are suitable for detection of diagnostically important changes in the metabolic profiles of biological fluids. A prototype instrument was employed to serve as an integrated platform for the analysis of urine sample from patients suffering from cancer cachexia. The instrument provides for convenient, rapid and efficient multidimensional approach towards method development which would facilitate simultaneous analysis of complex biological mixtures by the above techniques. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：183 / 192

页数：10

共 19 条

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