RecA family proteins in archaea: RadA and its cousins

被引：47

作者：

Haldenby, Sam ^{[1
]}

White, Malcolm F. ^{[2
]}

Allers, Thorsten ^{[1
]}

机构：

[1] Univ Nottingham, Sch Biol, Queens Med Ctr, Inst Genet, Nottingham NG7 2UH, England

[2] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2009年 / 37卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

archaeon; homologous recombination; RadA; RadB; Rad51; RecA; DNA STRAND EXCHANGE; HOMOLOGOUS RECOMBINATION; GENETIC INSTABILITY; CRYSTAL-STRUCTURE; ESCHERICHIA-COLI; TERMINAL DOMAIN; YEAST RAD51; REPAIR; POLYMERASE; FILAMENT;

D O I：

10.1042/BST0370102

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recombinases of the RecA family are essential for homologous recombination and underpin genome stability, by promoting the repair of double-stranded DNA breaks and the rescue of collapsed DNA replication forks. Until now, our understanding of homologous recombination has relied on studies of bacterial and eukaryotic model organisms. Archaea provide new opportunities to study how recombination operates in a lineage distinct from bacteria and eukaryotes. in the present paper, we focus on RadA, the archaeal RecA family recombinase, and its homologues in archaea and other domains. on the basis of phylogenetic analysis, we propose that a family of archaeal proteins with a single RecA domain, which are currently annotated as Kaic, be renamed aRadC.

引用

页码：102 / 107

页数：6

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