Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

被引：163

作者：

Jiang, Cheng-shi ^{[1
]}

Liang, Lin-fu ^{[1
]}

Guo, Yue-wei ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

ACTA PHARMACOLOGICA SINICA | 2012年 / 33卷 / 10期

基金：

欧盟第七框架计划;

关键词：

natural products; phytochemistry; protein tyrosine phosphatase 1B (PTP1B); inhibitor; structure-activity relationship (SAR); type; 2; diabetes; obesity; STEREOSELECTIVE TOTAL-SYNTHESIS; FORMAL RADICAL CYCLIZATION; SPONGE HYRTIOS-ERECTUS; STEM-BARK; ACID-DERIVATIVES; CHEMICAL-CONSTITUENTS; MACROCYCLIC POLYDISULFIDE; ISOPRENYLATED FLAVONOIDS; BIOLOGICAL EVALUATION; CONVENIENT SYNTHESIS;

D O I：

10.1038/aps.2012.90

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This article provides an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various natural sources or derived from synthetic process in the last decades. The structure-activity relationship and the selectivity of some compounds against other protein phosphatases were also discussed. Potential pharmaceutical applications of several PTP1B inhibitors were presented.

引用

页码：1217 / 1245

页数：29

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