Deletion of the laminin α4 chain leads to impaired microvessel maturation

被引:265
作者
Thyboll, J
Kortesmaa, J
Cao, RH
Soininen, R
Wang, L
Iivanainen, A
Sorokin, L
Risling, M
Cao, YH
Tryggvason, K [1 ]
机构
[1] Karolinska Inst, Dept Med Biochem & Biophys, Div Matrix Biol, S-17177 Stockholm, Sweden
[2] Karolinska Inst, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden
[3] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden
[4] Nikolaus Fiebiger Ctr, Interdisciplinary Ctr Clin Res, D-91045 Erlangen, Germany
关键词
D O I
10.1128/MCB.22.4.1194-1202.2002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The laminin alpha4 chain, a component of laminin-8 and -9, is expressed in basement membranes, such as those beneath endothelia, the perineurium of peripheral nerves, and around developing muscle fibers. Laminin alpha4-null mice presented with hemorrhages during the embryonic and neonatal period and had extensive bleeding and deterioration of microvessel growth in experimental angiogenesis, as well as mild locomotion defects. Histological examination of newborn mice revealed delayed deposition of type IV collagen and nidogen into capillary basement membranes, and electron microscopy showed discontinuities in the lamina densa. The results demonstrate a central role for the laminin alpha4 chain in microvessel growth and, in the absence of other laminin a chains, in the composition of endothelial basement membranes.
引用
收藏
页码:1194 / 1202
页数:9
相关论文
共 50 条
[1]   Vascular development: Cellular and molecular regulation [J].
Beck, L ;
DAmore, PA .
FASEB JOURNAL, 1997, 11 (05) :365-373
[2]   Vascular endothelial growth factor C induces angiogenesis in vivo [J].
Cao, YH ;
Linden, P ;
Farnebo, J ;
Cao, RH ;
Eriksson, A ;
Kumar, V ;
Qi, JH ;
Claesson-Welsh, L ;
Alitalo, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (24) :14389-14394
[3]   Angiogenesis inhibited by drinking tea [J].
Cao, YH ;
Cao, RH .
NATURE, 1999, 398 (6726) :381-381
[4]  
Colognato H, 2000, DEV DYNAM, V218, P213, DOI 10.1002/(SICI)1097-0177(200006)218:2<213::AID-DVDY1>3.0.CO
[5]  
2-R
[6]   Inhibition of laminin alpha 1-chain expression leads to alteration of basement membrane assembly and cell differentiation [J].
De Arcangelis, A ;
Neuville, P ;
Boukamel, R ;
Lefebvre, O ;
Kedinger, M ;
SimonAssmann, P .
JOURNAL OF CELL BIOLOGY, 1996, 133 (02) :417-430
[7]   Cloning of the mouse laminin alpha 4 cDNA. Expression in a subset of endothelium [J].
Frieser, M ;
Nockel, H ;
Pausch, F ;
Roder, C ;
Hahn, A ;
Deutzmann, R ;
Sorokin, LM .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 246 (03) :727-735
[8]   Chain specificity assignment of monoclonal antibodies to human laminins by using recombinant laminin β1 and γ1 chains [J].
Geberhiwot, T ;
Wondimu, Z ;
Salo, S ;
Pikkarainen, T ;
Kortesmaa, J ;
Tryggvason, K ;
Virtanen, I ;
Patarroyo, M .
MATRIX BIOLOGY, 2000, 19 (02) :163-167
[9]   Blood platelets contain and secrete laminin-8 (α4β1γ1) and adhere to laminin-8 via α6β1 integrin [J].
Geberhiwot, T ;
Ingerpuu, S ;
Pedraza, C ;
Neira, M ;
Lehto, U ;
Virtanen, I ;
Kortesmaa, J ;
Tryggvason, K ;
Engvall, E ;
Patarroyo, M .
EXPERIMENTAL CELL RESEARCH, 1999, 253 (02) :723-732
[10]   LOCALIZATION OF A MAJOR NIDOGEN-BINDING SITE TO DOMAIN-III OF LAMININ-B2 CHAIN [J].
GERL, M ;
MANN, K ;
AUMAILLEY, M ;
TIMPL, R .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 202 (01) :167-174