Biocatalytic synthesis of hydroxylated natural products using aldolases and related enzymes

被引：115

作者：

Fessner, WD

Helaine, V

机构：

[1] Tech Univ Darmstadt, Dept Organ Chem, D-64287 Darmstadt, Germany

[2] Univ Clermont Ferrand, Lab SEESIB, UMR 6504, F-63177 Aubiere, France

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2001年 / 12卷 / 06期

关键词：

D O I：

10.1016/S0958-1669(01)00265-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthetic building blocks bearing hydroxylated chiral centers are important targets for biocatalysis. Many C-C bond forming enzymes have recently been investigated for new applications and new strategies towards the synthesis of natural products and related oxygenated compounds. Several old catalysts have been studied to increase our functional knowledge of natural aldolase-type enzymes, and new mutated catalysts or catalytic antibodies have been tested for their synthetic utility.

引用

页码：574 / 586

页数：13

共 71 条

[41] Diversity of microbial threonine aldolases and their application
Liu, JQ
Dairi, T
Itoh, N
Kataoka, M
Shimizu, S
Yamada, H
[J]. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2000, 10 (1-3) : 107 - 115
[42] Mitchell M, 2001, ADV SYNTH CATAL, V343, P596, DOI 10.1002/1615-4169(200108)343:6/7<596::AID-ADSC596>3.0.CO
[43] 2-V
[44] An approach to the precise chemoenzymatic synthesis of 13C-labeled sialyloligosaccharide on an intact glycoprotein:: A novel one-pot [3-13C]-labeling method for sialic acid analogues by control of the reversible aldolase reaction, enzymatic synthesis of [3-13C]-NeuAc-α-(2→3)-[U-13C]-Gal-β-(1→4)-GlcNAc-β- sequence onto glycoprotein, and its conformational analysis by developed NMR techniques
Miyazaki, T
Sato, H
Sakakibara, T
Kajihara, Y
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (24) : 5678 - 5694
[45] Stereocontrolled chemoenzymatic synthesis of 2,3-disubstituted piperidines
Monterde, MI
Brieva, R
Gotor, V
[J]. TETRAHEDRON-ASYMMETRY, 2001, 12 (03) : 525 - 528
[46] Ouwerkerk N, 2000, EUR J ORG CHEM, V2000, P861
[47] Observation of unstable species in enzyme-catalyzed transformations using protein crystallography
Petsko, GA
Ringe, D
[J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2000, 4 (01) : 89 - 94
[48] Biosynthesis of isoprenoids.: A rapid method for the preparation of isotope-labeled 4-diphosphocytidyl-2C-methyl-D-erythritol
Rohdich, F
Schuhr, CA
Hecht, S
Herz, S
Wungsintaweekul, J
Eisenreich, W
Zenk, MH
Bacher, A
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (40) : 9571 - 9574
[49] Chemo-enzymatic total synthesis of 3-epiaustraline, australine, and 7-epialexine
Romero, A
Wong, CH
[J]. JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (24) : 8264 - 8268
[50] Schoevaart R, 2000, BIOTECHNOL BIOENG, V70, P349, DOI 10.1002/1097-0290(20001105)70:3<349::AID-BIT12>3.0.CO

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