Stereocontrolled chemoenzymatic synthesis of 2,3-disubstituted piperidines

被引：22

作者：

Monterde, MI ^{[1
]}

Brieva, R ^{[1
]}

Gotor, V ^{[1
]}

机构：

[1] Univ Oviedo, Fac Quim, Dept Quim Organ & Inorgan, Oviedo 33006, Spain

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(01)00080-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(R,R)-2,3-Disubstituted piperidines were readily synthesized starting from (R)-(+)- 5-bromo-2-hydroxypentanenitrile (R)-2. An enantioselective (R)-oxynitrilase-catalyzed transcyanation was used to prepare the starting cyanohydrin (R)-2. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：525 / 528

页数：4

共 12 条

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