Chemoenzymatic synthesis of azacycloalkan-3-ols

被引：36

作者：

Monterde, MI ^{[1
]}

Nazabadioko, S ^{[1
]}

Rebolledo, F ^{[1
]}

Brieva, R ^{[1
]}

Gotor, V ^{[1
]}

机构：

[1] Univ Oviedo, Fac Quim, Dept Quim Organ & Inorgan, E-33071 Oviedo, Spain

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 17期

关键词：

D O I：

10.1016/S0957-4166(99)00351-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Optically active omega-bromocyanohydrins are easily synthesized through an enantioselective (R)-oxynitrilase-catalyzed reaction from their corresponding omega-bromoaldehydes. These cyanohydrins are starting materials for the preparation of medium size nitro gen heterocycles. The reduction of (R)-(+)-5-bromo-2-hydroxypentanenitrile affords, in one-pot, piperidin-3-ol. Azepan-3-ol and azocan-3-ol are readily obtained from their corresponding cyanohydrins in high enantiomeric excesses. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3449 / 3455

页数：7

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