Environmental and Genetic Risk Factors in Obesity

被引：89

作者：

Hebebrand, Johannes ^{[1
]}

Hinney, Anke ^{[1
]}

机构：

[1] Univ Duisburg Essen, Rhein Kliniken Essen, Dept Child & Adolescent Psychiat, D-45147 Essen, Germany

来源：

CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA | 2009年 / 18卷 / 01期

关键词：

Monogenic; Polygenic; Socioeconomic status; Television; BODY-MASS INDEX; GENOME-WIDE ASSOCIATION; CHILDHOOD OBESITY; PHYSICAL-ACTIVITY; SOCIOECONOMIC-STATUS; ENERGY-EXPENDITURE; SOCIAL-CLASS; FAT MASS; CHILDREN; WEIGHT;

D O I：

10.1016/j.chc.2008.07.006

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Because of its high prevalence and the associated medical and psychosocial risks, research into the causes of childhood obesity has experienced a tremendous upswing. Formal genetic data based on twin, adoption, and family studies lead to the conclusion that at least 50% of the interindividual variance of the body mass index (BMI; defined as weight in kilograms divided by height in meters squared) is due to genetic factors. As a result of the recent advent of genome-wide association studies, the first

引用

页码：83 / +

页数：14

共 89 条

[1] Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation [J].

Andreasen, Camilla H. ;

Stender-Petersen, Kirstine L. ;

Mogensen, Mette S. ;

Torekov, Signe S. ;

Wegner, Lise ;

Andersen, Gitte ;

Nielsen, Arne L. ;

Albrechtsen, Anders ;

Borch-Johnsen, Knut ;

Rasmussen, Signe S. ;

Clausen, Jesper O. ;

Sandbaek, Annelli ;

Lauritzen, Torsten ;

Hansen, Lars ;

Jorgensen, Torben ;

Pedersen, Oluf ;

Hansen, Torben .

DIABETES, 2008, 57 (01) :95-101

[2] Breast-feeding and childhood obesity -: a systematic review [J].

Arenz, S ;

Rückerl, R ;

Koletzko, B ;

von Kries, R .

INTERNATIONAL JOURNAL OF OBESITY, 2004, 28 (10) :1247-1256

[3] Familial influences and obesity-associated metabolic risk factors contribute to the variation in resting energy expenditure:: the Kiel Obesity Prevention Study [J].

Bosy-Westphal, Anja ;

Wolf, Andreas ;

Buehrens, Frederike ;

Hitze, Britta ;

Czech, Norbert ;

Moenig, Heiner ;

Selberg, Oliver ;

Settler, Uta ;

Pfeuffer, Maria ;

Schrezenmeir, Juergen ;

Krawczak, Michael ;

Mueller, Manfred J. .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2008, 87 (06) :1695-1701

[4] THE RESPONSE TO LONG-TERM OVERFEEDING IN IDENTICAL-TWINS [J].

BOUCHARD, C ;

TREMBLAY, A ;

DESPRES, JP ;

NADEAU, A ;

LUPIEN, PJ ;

THERIAULT, G ;

DUSSAULT, J ;

MOORJANI, S ;

PINAULT, S ;

FOURNIER, G .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (21) :1477-1482

[5] Binge eating as a major phenotype of melanocortin 4 receptor gene mutations [J].

Branson, R ;

Potoczna, N ;

Kral, JG ;

Lentes, K ;

Hoehe, MR ;

Horber, FF .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (12) :1096-1103

[6] The epidemic of obesity and changes in food intake: the Fluoride Hypothesis [J].

Bray, GA .

PHYSIOLOGY & BEHAVIOR, 2004, 82 (01) :115-121

[7] Obesity in childhood and personality development (reprinted from American Journal of Orthopsychiatry, vol 11, pg 467-473, 1941) [J].

Bruch, H .

OBESITY RESEARCH, 1997, 5 (02) :157-161

[8]

BRUCH H, 1964, PSYCHOSOMATICS, V5, P269

[9] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[10]

Centers for Disease Control and Prevention (CDC), 2003, MMWR Morb Mortal Wkly Rep, V52, P785

← 1 2 3 4 5 6 7 8 9 →