Environmental and Genetic Risk Factors in Obesity

被引：89

作者：

Hebebrand, Johannes ^{[1
]}

Hinney, Anke ^{[1
]}

机构：

[1] Univ Duisburg Essen, Rhein Kliniken Essen, Dept Child & Adolescent Psychiat, D-45147 Essen, Germany

来源：

CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA | 2009年 / 18卷 / 01期

关键词：

Monogenic; Polygenic; Socioeconomic status; Television; BODY-MASS INDEX; GENOME-WIDE ASSOCIATION; CHILDHOOD OBESITY; PHYSICAL-ACTIVITY; SOCIOECONOMIC-STATUS; ENERGY-EXPENDITURE; SOCIAL-CLASS; FAT MASS; CHILDREN; WEIGHT;

D O I：

10.1016/j.chc.2008.07.006

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Because of its high prevalence and the associated medical and psychosocial risks, research into the causes of childhood obesity has experienced a tremendous upswing. Formal genetic data based on twin, adoption, and family studies lead to the conclusion that at least 50% of the interindividual variance of the body mass index (BMI; defined as weight in kilograms divided by height in meters squared) is due to genetic factors. As a result of the recent advent of genome-wide association studies, the first

引用

页码：83 / +

页数：14

共 89 条

[31] Epidemic obesity: are genetic factors involved via increased rates of assortative mating? [J].

Hebebrand, J ;

Wulftange, H ;

Goerg, T ;

Ziegler, A ;

Hinney, A ;

Barth, N ;

Mayer, H ;

Remschmidt, H .

INTERNATIONAL JOURNAL OF OBESITY, 2000, 24 (03) :345-353

[32]

Hebebrand J, 2005, ADIPOSITAS BEI KINDE, P50

[33]

Hebebrand J, 2004, PEDIATR ADOLESC MED, V9, P80

[34] Association of the 1031 MC4R allele with decreased body mass in 7937 participants of two population based surveys -: art. no. e21 [J].

Heid, IM ;

Vollmert, C ;

Hinney, A ;

Döring, A ;

Geller, F ;

Löwel, H ;

Wichmann, HE ;

Illig, T ;

Hebebrand, J ;

Kronenberg, F .

JOURNAL OF MEDICAL GENETICS, 2005, 42 (04)

[35] A common genetic variant is associated with adult and childhood obesity [J].

Herbert, A ;

Gerry, NP ;

McQueen, MB ;

Heid, IM ;

Pfeufer, A ;

Illig, T ;

Wichmann, HE ;

Meitinger, T ;

Hunter, D ;

Hu, FB ;

Colditz, G ;

Hinney, A ;

Hebebrand, J ;

Koberwitz, K ;

Zhu, XF ;

Cooper, R ;

Ardlie, K ;

Lyon, H ;

Hirschhorn, JN ;

Laird, NM ;

Lenburg, ME ;

Lange, C ;

Christman, MF .

SCIENCE, 2006, 312 (5771) :279-283

[36]

Herpertz S, 2003, NEW ENGL J MED, V349, P606

[37] Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany [J].

Hinney, A ;

Bettecken, T ;

Tarnow, P ;

Brumm, H ;

Reichwald, K ;

Lichtner, P ;

Scherag, A ;

Nguyen, TT ;

Schlumberger, P ;

Rief, W ;

Vollmert, C ;

Illig, T ;

Wichmann, HE ;

Schäfer, H ;

Platzer, M ;

Biebermann, H ;

Meitinger, T ;

Hebebrand, J .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (05) :1761-1769

[38] Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants [J].

Hinney, Anke ;

Nguyen, Thuy Trang ;

Scherag, Andre ;

Friedel, Susann ;

Broenner, Guenter ;

Mueller, Timo Dirk ;

Grallert, Harald ;

Illig, Thomas ;

Wichmann, H. -Erich ;

Rief, Winfried ;

Schaefer, Helmut ;

Hebebrand, Johannes .

PLOS ONE, 2007, 2 (12)

[39] Social class, parental education, and obesity prevalence in a study of six-year-old children in Germany [J].

Lamerz, A ;

Kuepper-Nybelen, J ;

Wehle, C ;

Bruning, N ;

Trost-Brinkhues, G ;

Brenner, H ;

Hebebrand, J ;

Herpertz-Dahlmann, B .

INTERNATIONAL JOURNAL OF OBESITY, 2005, 29 (04) :373-380

[40] Social class differences in overweight of prepubertal children in northwest Germany [J].

Langnäse, K ;

Mast, M ;

Müller, MJ .

INTERNATIONAL JOURNAL OF OBESITY, 2002, 26 (04) :566-572

← 1 2 3 4 5 6 7 8 9 →