Follicular helper T cells in the pathogenesis of IgG4-related disease

被引：82

作者：

Akiyama, Mitsuhiro ^{[1
]}

Suzuki, Katsuya ^{[1
]}

Yasuoka, Hidekata ^{[1
]}

Kaneko, Yuko ^{[1
]}

Yamaoka, Kunihiro ^{[1
]}

Takeuchi, Tsutomu ^{[1
]}

机构：

[1] Keio Univ, Div Rheumatol, Dept Internal Med, Sch Med, Tokyo, Japan

来源：

RHEUMATOLOGY | 2018年 / 57卷 / 02期

关键词：

IgG4-related disease; pathogenesis; T lymphocyte; T follicular helper cell; germinal centre; plasmablast; somatic hypermutation; interleukin-4; interleukin-21; CHURG-STRAUSS-SYNDROME; PRIMARY SCLEROSING CHOLANGITIS; REGULATORY IMMUNE-REACTIONS; LACRIMAL GLAND ENLARGEMENT; CLASS-SWITCH RECOMBINATION; GERMINAL CENTER FORMATION; CYTIDINE DEAMINASE AID; MIKULICZS-DISEASE; B-CELLS; AUTOIMMUNE PANCREATITIS;

D O I：

10.1093/rheumatology/kex171

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

IgG4-related disease (IgG4-RD) is a recently recognized disease entity characterized by high serum IgG4 concentrations and infiltration of IgG4(+) plasma cells with hyperplastic ectopic germinal centres at affected sites. Although the underlying immune mechanism of this disease remains unclear, T cells are abundantly present at affected sites and key players in IgG4-RD pathogenesis. The role of T cell subsets has been investigated thoroughly in this disease. Recent advances in this field have clarified the importance of T follicular helper cells. In this review, we describe the role of T follicular helper cells in the disease process of IgG4-RD, in particular, for IgG4 class-switching, plasmablast and plasma cell differentiation, and germinal centre formation.

引用

页码：236 / 245

页数：10

共 110 条

[1]

Immunoglobulin G4: an odd antibody [J].

Aalberse, R. C. ;

Stapel, S. O. ;

Schuurman, J. ;

Rispens, T. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2009, 39 (04) :469-477

[2]

Akiyama M, 2015, CLIN EXP RHEUMATOL, V33, P949

[3]

Enhanced IgG4 production by follicular helper 2 T cells and the involvement of follicular helper 1 T cells in the pathogenesis of IgG4-related disease [J].

Akiyama, Mitsuhiro ;

Yasuoka, Hidekata ;

Yamaoka, Kunihiro ;

Suzuki, Katsuya ;

Kaneko, Yuko ;

Kondo, Harumi ;

Kassai, Yoshiaki ;

Koga, Keiko ;

Miyazaki, Takahiro ;

Morita, Rimpei ;

Yoshimura, Akihiko ;

Takeuchi, Tsutomu .

ARTHRITIS RESEARCH & THERAPY, 2016, 18

[4]

Akiyama, Mitsuhiro ;

Kaneko, Yuko ;

Hayashi, Yutaro ;

Takeuchi, Tsutomu .

MEDICINE, 2016, 95 (24)

[5]

Resolution of elevated circulating regulatory T cells by corticosteroids in patients with IgG4-related dacryoadenitis and sialoadenitis [J].

Akiyama, Mitsuhiro ;

Suzuki, Katsuya ;

Kassai, Yoshiaki ;

Miyazaki, Takahiro ;

Morita, Rimpei ;

Yoshimura, Akihiko ;

Takeuchi, Tsutomu .

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2016, 19 (04) :430-432

[6]

Brief Report Number of Circulating Follicular Helper 2 T Cells Correlates With IgG4 and Interleukin-4 Levels and Plasmablast Numbers in IgG4-Related Disease [J].

Akiyama, Mitsuhiro ;

Suzuki, Katsuya ;

Yamaoka, Kunihiro ;

Yasuoka, Hidekata ;

Takeshita, Masaru ;

Kaneko, Yuko ;

Kondo, Harumi ;

Kassai, Yoshiaki ;

Miyazaki, Takahiro ;

Morita, Rimpei ;

Yoshimura, Akihiko ;

Takeuchi, Tsutomu .

ARTHRITIS & RHEUMATOLOGY, 2015, 67 (09) :2476-2481

[7]

Could abatacept directly target expanded plasmablasts in IgG4-related disease? [J].

Alegria, Guillermo Carvajal ;

Pochard, Pierre ;

Pers, Jacques-Olivier ;

Cornec, Divi .

ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 (11) :E73-U5

[8]

Dances with cytokines, featuring TFH cells, IL-21, IL-4 and B cells [J].

Belanger, Simon ;

Crotty, Shane .

NATURE IMMUNOLOGY, 2016, 17 (10) :1135-1136

[9]

BORDER WA, 1994, NEW ENGL J MED, V331, P1286

[10]

Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production [J].

Breitfeld, D ;

Ohl, L ;

Kremmer, E ;

Ellwart, J ;

Sallusto, F ;

Lipp, M ;

Förster, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (11) :1545-1551

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