Follicular helper T cells in the pathogenesis of IgG4-related disease

被引：82

作者：

Akiyama, Mitsuhiro ^{[1
]}

Suzuki, Katsuya ^{[1
]}

Yasuoka, Hidekata ^{[1
]}

Kaneko, Yuko ^{[1
]}

Yamaoka, Kunihiro ^{[1
]}

Takeuchi, Tsutomu ^{[1
]}

机构：

[1] Keio Univ, Div Rheumatol, Dept Internal Med, Sch Med, Tokyo, Japan

来源：

RHEUMATOLOGY | 2018年 / 57卷 / 02期

关键词：

IgG4-related disease; pathogenesis; T lymphocyte; T follicular helper cell; germinal centre; plasmablast; somatic hypermutation; interleukin-4; interleukin-21; CHURG-STRAUSS-SYNDROME; PRIMARY SCLEROSING CHOLANGITIS; REGULATORY IMMUNE-REACTIONS; LACRIMAL GLAND ENLARGEMENT; CLASS-SWITCH RECOMBINATION; GERMINAL CENTER FORMATION; CYTIDINE DEAMINASE AID; MIKULICZS-DISEASE; B-CELLS; AUTOIMMUNE PANCREATITIS;

D O I：

10.1093/rheumatology/kex171

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

IgG4-related disease (IgG4-RD) is a recently recognized disease entity characterized by high serum IgG4 concentrations and infiltration of IgG4(+) plasma cells with hyperplastic ectopic germinal centres at affected sites. Although the underlying immune mechanism of this disease remains unclear, T cells are abundantly present at affected sites and key players in IgG4-RD pathogenesis. The role of T cell subsets has been investigated thoroughly in this disease. Recent advances in this field have clarified the importance of T follicular helper cells. In this review, we describe the role of T follicular helper cells in the disease process of IgG4-RD, in particular, for IgG4 class-switching, plasmablast and plasma cell differentiation, and germinal centre formation.

引用

页码：236 / 245

页数：10

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