Selective recognition of a C-G base-pair in the parallel DNA triple-helical binding motif

被引：54

作者：

Prévot-Halter, I ^{[1
]}

Leumann, CJ ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(99)00451-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Selective recognition of a C-G base-pair within the parallel DNA triple-helical binding motif was achieved by a third strand containing the base 5-methyl pyrimidin-2-one. The third strand affinities (K-D) for a representative 15-mer duplex sequence containing all four Watson-Crick base pairs (X-Y) in the center are C-G (26 nM) >> A-T (270 nM) similar to T-A (350 nM) > G-C (ca. 700 nM). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2657 / 2660

页数：4

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