Blood-brain barrier dysfunction and recovery

被引：50

作者：

de Boer, AG ^{[1
]}

Gaillard, PJ ^{[1
]}

机构：

[1] Leiden Univ, Amsterdam Ctr Drug Res, Div Pharmacol, Blood Brain Barrier Res Grp,Gorlaeus Lab, NL-2300 RA Leiden, Netherlands

来源：

JOURNAL OF NEURAL TRANSMISSION | 2006年 / 113卷 / 04期

关键词：

In vitro blood-brain barrier; cell culture; permeability; inflammatory disease; gluocorticoids; interferon-alpha; beta;

D O I：

10.1007/s00702-005-0375-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this paper we discuss the importance of the blood-brain barrier (BBB) as an interface between blood and brain. Many (brain) diseases change the functionality and integrity of the BBB. Mostly this results in increased BBB permeability. Therefore we have studied de various signal transduction routes that are influenced by inflammatory stimuli. The radical scavenger N-acetylcysteine was able to protect the BBB against inflammatory stimuli. Similar results were found following application of glucocorticoids. In addition, it was observed that glucocorticoids and interferon-alpha,beta increased the tightness of the in vitro BBB and when given together a potentiating effect was seen.

引用

页码：455 / 462

页数：8

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