Inhibition of Lassa and Marburg Virus Production by Tetherin

被引：241

作者：

Sakuma, Toshie ^{[1
]}

Noda, Takeshi ^{[2
]}

Urata, Shuzo ^{[1
]}

Kawaoka, Yoshihiro ^{[2
,3
]}

Yasuda, Jiro ^{[1
]}

机构：

[1] Natl Res Inst Police Sci, Dept Forens Sci 1, Kashiwa, Chiba 2770882, Japan

[2] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol, Tokyo 1088639, Japan

[3] Univ Wisconsin, Sch Vet Med, Dept Pathol Sci, Madison, WI 53706 USA

来源：

JOURNAL OF VIROLOGY | 2009年 / 83卷 / 05期

关键词：

CELL-SURFACE; EBOLA-VIRUS; MOLECULAR-CLONING; VPU PROTEIN; HIV-1; VPU; RELEASE; PARTICLES; MOTIF;

D O I：

10.1128/JVI.01607-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recently, tetherin has been identified as an effective cellular factor that prevents the release of human immunodeficiency virus type 1. Here, we show that the production of virus-like particles induced by viral matrix proteins of Lassa virus or Marburg virus was markedly inhibited by tetherin and that N-linked glycosylation of tetherin was dispensable for this antiviral activity. Our data also suggest that viral matrix proteins or one or more components that originate from host cells are targets of tetherin but that viral surface glycoproteins are not. These results suggest that tetherin inhibits the release of a wide variety of enveloped viruses from host cells by a common mechanism.

引用

页码：2382 / 2385

页数：4

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