A new and efficient one-pot synthesis of apomorphine and its ring-a halogenated derivatives

被引：18

作者：

Csutoras, C ^{[1
]}

Berenyi, S ^{[1
]}

Makleit, S ^{[1
]}

机构：

[1] LAJOS KOSSUTH UNIV,DEPT ORGAN CHEM,H-4010 DEBRECEN,HUNGARY

来源：

SYNTHETIC COMMUNICATIONS | 1996年 / 26卷 / 12期

关键词：

D O I：

10.1080/00397919608004535

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rearrangement and O-demethylation of codeine (2) and various 6-demethoxythebaine derivatives 6-11 with morphinane skeletone into apomorphine (3) and its halogenated derivatives 20-24 could, be efficiently executed in a one-pot operation, by treatment with methanesulfonic acid/methionine.

引用

页码：2251 / 2256

页数：6

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