Uniformly colorized beads for multiplex immunoassay

被引：51

作者：

Zhao, XW

Liu, ZB

Yang, H

Nagai, K

Zhao, YH

Gu, ZZ ^{[1
]}

机构：

[1] Southeast Univ, State Key Lab Bioelect, Nanjing 210096, Peoples R China

[2] Zhejiang Univ, Coll Life Sci, Hangzhou 310029, Peoples R China

[3] Osaka Univ, Inst Laser Engn, Osaka 5650871, Japan

来源：

CHEMISTRY OF MATERIALS | 2006年 / 18卷 / 09期

关键词：

D O I：

10.1021/cm060283f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We introduced a fluidic droplet generation method for the generation of monodispersed polymer beads with structural color. Multicolorized polystyrene beads were derived by embedding pearl pigment. Methods for generating uniform color and controlling bead size and surface were developed to make the beads suitable for multiplex immunoassay. A multiplex assay of antigen-antibody interaction shows that the multicolored encoded bead is a stable and cost-effective microcarrier. Wide applications in genomic or proteomic studies, drug screening, clinical diagnostics, and combinatorial chemical fields are anticipated.

引用

页码：2443 / 2449

页数：7

共 43 条

[1] Novel miniaturized systems in high-throughput screening [J].