Regioselective synthesis of N-β-hydroxyethylaziridines by the ring-opening reaction of epoxides with aziridine generated in situ

被引：20

作者：

Kim, HY ^{[1
]}

Talukdar, A

Cushman, M

机构：

[1] Purdue Univ, Sch Pharm & Pharmaceut Sci, Dept Med Chem, W Lafayette, IN 47907 USA

[2] Purdue Univ, Sch Pharm & Pharmaceut Sci, Purdue Canc Ctr, W Lafayette, IN 47907 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 06期

关键词：

D O I：

10.1021/ol0529703

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Biologically important N-beta-hydroxyethylaziridine intermediates were conveniently prepared by regioselective ring-opening reactions of diversely substituted epoxides. Ethyleneimine generated in situ under basic conditions from beta-chloroethylamine was used as a nucleophile to open the epoxides in an aqueous environment.

引用

页码：1085 / 1087

页数：3

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