Modelling HIV infection and therapies in humanised mice

被引：21

作者：

Nischang, Marc ^{[1
]}

Gers-Huber, Gustavo ^{[1
]}

Audige, Annette ^{[1
]}

Akkina, Ramesh ^{[2
]}

Speck, Roberto F. ^{[1
]}

机构：

[1] Univ Zurich, Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, CH-8091 Zurich, Switzerland

[2] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

来源：

SWISS MEDICAL WEEKLY | 2012年 / 142卷

基金：

瑞士国家科学基金会;

关键词：

HIV-1; infection; HIV pathogenesis; humanised mice; BLT mice; SCID; human CD34+cells; gene therapy; CCR5; antiretroviral treatment; microbicides; HIV pre-exposure prophylaxis (PrEP); HUMAN-IMMUNODEFICIENCY-VIRUS; HEMATOPOIETIC STEM-CELLS; PBL-SCID MICE; HUMAN IMMUNE-SYSTEM; AIDS-LIKE DISEASE; CD4(+) T-CELLS; RAG-HU MICE; IN-VIVO; MOUSE MODEL; TRANSGENIC MICE;

D O I：

10.4414/smw.2012.13618

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The human immunodeficiency virus (HIV) type-1 is a human-specific virus. The lack of a widely available small-animal model has seriously hampered HIV research. In 2004, a new humanised mouse model was reported. It was based on the intrahepatic injection of human CD34+ cord blood cells into newborn, highly immunodeficient mice. These mice develop a lymphoid system of human origin and are highly susceptible to HIV infection and showed disseminated infection, persistent viraemia and characteristic helper CD4+ T-cell loss. Here, we will briefly review the various existing humanised mouse models and highlight their value to the study of HIV infection.

引用

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