Modelling HIV infection and therapies in humanised mice

被引：21

作者：

Nischang, Marc ^{[1
]}

Gers-Huber, Gustavo ^{[1
]}

Audige, Annette ^{[1
]}

Akkina, Ramesh ^{[2
]}

Speck, Roberto F. ^{[1
]}

机构：

[1] Univ Zurich, Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, CH-8091 Zurich, Switzerland

[2] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

来源：

SWISS MEDICAL WEEKLY | 2012年 / 142卷

基金：

瑞士国家科学基金会;

关键词：

HIV-1; infection; HIV pathogenesis; humanised mice; BLT mice; SCID; human CD34+cells; gene therapy; CCR5; antiretroviral treatment; microbicides; HIV pre-exposure prophylaxis (PrEP); HUMAN-IMMUNODEFICIENCY-VIRUS; HEMATOPOIETIC STEM-CELLS; PBL-SCID MICE; HUMAN IMMUNE-SYSTEM; AIDS-LIKE DISEASE; CD4(+) T-CELLS; RAG-HU MICE; IN-VIVO; MOUSE MODEL; TRANSGENIC MICE;

D O I：

10.4414/smw.2012.13618

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The human immunodeficiency virus (HIV) type-1 is a human-specific virus. The lack of a widely available small-animal model has seriously hampered HIV research. In 2004, a new humanised mouse model was reported. It was based on the intrahepatic injection of human CD34+ cord blood cells into newborn, highly immunodeficient mice. These mice develop a lymphoid system of human origin and are highly susceptible to HIV infection and showed disseminated infection, persistent viraemia and characteristic helper CD4+ T-cell loss. Here, we will briefly review the various existing humanised mouse models and highlight their value to the study of HIV infection.

引用

页数：29

共 133 条

[51] Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantaion [J].

Huetter, Gero ;

Nowak, Daniel ;

Mossner, Maximilian ;

Ganepola, Susanne ;

Muessig, Arne ;

Allers, Kristina ;

Schneider, Thomas ;

Hofmann, Joerg ;

Kuecherer, Claudia ;

Blau, Olga ;

Blau, Igor W. ;

Hofmann, Wolf K. ;

Thiel, Eckhard .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (07) :692-698

[52]

Ince WL, J VIROL, V84, P2740

[53] NOD/SCID/γcnull mouse:: an excellent recipient mouse model for engraftment of human cells [J].

Ito, M ;

Hiramatsu, H ;

Kobayashi, K ;

Suzue, K ;

Kawahata, M ;

Hioki, K ;

Ueyama, Y ;

Koyanagi, Y ;

Sugamura, K ;

Tsuji, K ;

Heike, T ;

Nakahata, T .

BLOOD, 2002, 100 (09) :3175-3182

[54] Mortality in the Swiss HIV Cohort Study (SHCS) and the Swiss general population [J].

Jaggy, C ;

von Overbeck, J ;

Ledergerber, B ;

Schwarz, C ;

Egger, M ;

Rickenbach, M ;

Furrer, HJ ;

Telenti, A ;

Battegay, M ;

Flepp, M ;

Vernazza, P ;

Bernasconi, E ;

Hirschel, B .

LANCET, 2003, 362 (9387) :877-878

[55] Dengue Virus Infection and Virus-Specific HLA-A2 Restricted Immune Responses in Humanized NOD-scid IL2rγnull Mice [J].

Jaiswal, Smita ;

Pearson, Todd ;

Friberg, Heather ;

Shultz, Leonard D. ;

Greiner, Dale L. ;

Rothman, Alan L. ;

Mathew, Anuja .

PLOS ONE, 2009, 4 (10)

[56] FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-γC-/- mice in vivo [J].

Jiang, Qi ;

Zhang, Liguo ;

Wang, Rui ;

Jeffrey, Jerry ;

Washburn, Michael L. ;

Brouwer, Dedeke ;

Barbour, Selena ;

Kovalev, Grigoriy I. ;

Unutmaz, Derya ;

Su, Lishan .

BLOOD, 2008, 112 (07) :2858-2868

[57] Inhibition of In Vivo HIV Infection in Humanized Mice by Gene Therapy of Human Hematopoietic Stem Cells with a Lentiviral Vector Encoding a Broadly Neutralizing Anti-HIV Antibody [J].

Joseph, Aviva ;

Zheng, Jian Hua ;

Chen, Ken ;

Dutta, Monica ;

Chen, Cindy ;

Stiegler, Gabriela ;

Kunert, Renate ;

Follenzi, Antonia ;

Goldstein, Harris .

JOURNAL OF VIROLOGY, 2010, 84 (13) :6645-6653

[58] Hematopoietic-Stem-Cell-Based Gene Therapy for HIV Disease [J].

Kiem, Hans-Peter ;

Jerome, Keith R. ;

Deeks, Steven G. ;

McCune, Joseph M. .

CELL STEM CELL, 2012, 10 (02) :137-147

[59] RNAi-mediated CCR5 Silencing by LFA-1-targeted Nanoparticles Prevents HIV Infection in BLT Mice [J].

Kim, Sang-Soo ;

Peer, Dan ;

Kumar, Priti ;

Subramanya, Sandesh ;

Wu, Huaquan ;

Asthana, Deshratan ;

Habiro, Katsuyoshi ;

Yang, Yong-Guang ;

Manjunath, N. ;

Shimaoka, Motomu ;

Shankar, Premlata .

MOLECULAR THERAPY, 2010, 18 (02) :370-376

[60] T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice [J].

Kumar, Priti ;

Ban, Hong-Seok ;

Kim, Sang-Soo ;

Wu, Haoquan ;

Pearson, Todd ;

Greiner, Dale L. ;

Laouar, Amale ;

Yao, Jiahong ;

Haridas, Viraga ;

Habiro, Katsuyoshi ;

Yang, Yong-Guang ;

Jeong, Ji-Hoon ;

Lee, Kuen-Yong ;

Kim, Yong-Hee ;

Kim, Sung Wan ;

Peipp, Matthias ;

Fey, Georg H. ;

Manjunath, N. ;

Shultz, Leonard D. ;

Lee, Sang-Kyung ;

Shankar, Premlata .

CELL, 2008, 134 (04) :577-586

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