Macrolactones in diversity-oriented synthesis: Preparation of a pilot library and exploration of factors controlling macrocyclization

被引:33
作者
Schmidt, DR [1 ]
Kwon, O [1 ]
Schreiber, SL [1 ]
机构
[1] Harvard Univ, Howard Hughes Med Inst, Dept Chem & Chem Biol, ICCB, Cambridge, MA 02138 USA
来源
JOURNAL OF COMBINATORIAL CHEMISTRY | 2004年 / 6卷 / 02期
关键词
D O I
10.1021/cc020076m
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
[No abstract available]
引用
收藏
页码:286 / 292
页数:7
相关论文
共 51 条
[31]  
Nicolaou KC, 1998, ANGEW CHEM INT EDIT, V37, P2534, DOI 10.1002/(SICI)1521-3773(19981002)37:18<2534::AID-ANIE2534>3.0.CO
[32]  
2-F
[33]   Designed epothilones: Combinatorial synthesis, tubulin assembly properties, and cytotoxic action against taxol-resistant tumor cells [J].
Nicolaou, KC ;
Vourloumis, D ;
Li, TH ;
Pastor, J ;
Winssinger, N ;
He, Y ;
Ninkovic, S ;
Sarabia, F ;
Vallberg, H ;
Roschangar, F ;
King, NP ;
Finlay, MRV ;
Giannakakou, P ;
VerdierPinard, P ;
Hamel, E .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1997, 36 (19) :2097-2103
[34]   TRANSESTERIFICATION [J].
OTERA, J .
CHEMICAL REVIEWS, 1993, 93 (04) :1449-1470
[35]   Facile macrocyclizations to β-turn mimics with diverse structural, physical, and conformational properties [J].
Park, C ;
Burgess, K .
JOURNAL OF COMBINATORIAL CHEMISTRY, 2001, 3 (03) :257-266
[36]   Solid phase combinatorial synthesis of a library of macro-heterocycles and related acyclic compounds [J].
Ramaseshan, M ;
Dory, YL ;
Deslongchamps, P .
JOURNAL OF COMBINATORIAL CHEMISTRY, 2000, 2 (06) :615-623
[37]   Design and synthesis of macro-heterocycles structurally related to tirofiban [J].
Ramaseshan, M ;
Robitaille, M ;
Ellingboe, JW ;
Dory, YL ;
Deslongchamps, P .
TETRAHEDRON LETTERS, 2000, 41 (24) :4737-4742
[38]  
Reichwein JF, 1999, ANGEW CHEM INT EDIT, V38, P3684, DOI 10.1002/(SICI)1521-3773(19991216)38:24<3684::AID-ANIE3684>3.0.CO
[39]  
2-M
[40]   Preferred secondary structures as a possible driving force for macrocyclization [J].
Reyes, S ;
Pattarawarapan, M ;
Roy, S ;
Burgess, K .
TETRAHEDRON, 2000, 56 (50) :9809-9818