Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV

被引：763

作者：

Moore, PS

Boshoff, C

Weiss, RA

Chang, Y

机构：

[1] COLUMBIA UNIV, DEPT PATHOL, NEW YORK, NY 10032 USA

[2] INST CANC RES, CHESTER BEATTY LABS, LONDON SW3 6JB, ENGLAND

来源：

SCIENCE | 1996年 / 274卷 / 5293期

关键词：

D O I：

10.1126/science.274.5293.1739

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome. vIL-6 was functional in B9 proliferation assays and primarily expressed in KSHV-infected hematopoietic cells rather than KS lesions. HIV-1 transmission studies showed that vMIP-I is similar to human MIP chemokines in its ability to inhibit replication of HIV-1 strains dependent on the CCR5 co-receptor. These viral genes may form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-1 interactions.

引用

页码：1739 / 1744

页数：6

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