Angiogenesis in hematologic malignancies

被引：56

作者：

Moehler, TM ^{[1
]}

Neben, K ^{[1
]}

Ho, AD ^{[1
]}

Goldschmidt, H ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Internal Med 5, D-69115 Heidelberg, Germany

来源：

ANNALS OF HEMATOLOGY | 2001年 / 80卷 / 12期

关键词：

angiogenesis; vasculogenesis; leukemia; lymphoma; multiple myeloma;

D O I：

10.1007/s00277-001-0398-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiogenesis defined as the blood vessel generation from preexisting blood vessels was found to play an important role in the progression of solid tumors. In addition, bone marrow-derived endothelial precursor cells may contribute to tumor angiogenesis. Recently angiogenesis induction was described in several hematologic neoplasms as leukemia, lymphoma, myelodysplastic syndrome and multiple myeloma (MM). Clinical angiogenesis research also termed as angiodiagnosis has established the prognostic relevance of markers of angiogenesis e.g., microvessel density and circulating levels of angiogenic peptides. Development of antiangiogenic treatment for hematologic neoplasms has recently been sparked by the success of Thalidomide (Thal) which has antiangiogenic properties in MM. Antiangiogenic treatment strategies are now being tested in clinical trials on several types of hematologic neoplasms.

引用

页码：695 / 705

页数：11

共 129 条

[11] INDUCTION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR EXPRESSION IN SYNOVIAL FIBROBLASTS BY PROSTAGLANDIN-E AND INTERLEUKIN-1 - A POTENTIAL MECHANISM FOR INFLAMMATORY ANGIOGENESIS [J].

BENAV, P ;

CROFFORD, LJ ;

WILDER, RL ;

HLA, T .

FEBS LETTERS, 1995, 372 (01) :83-87

[12] Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal [J].

Benjamin, LE ;

Keshet, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (16) :8761-8766

[13] Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal [J].

Benjamin, LE ;

Golijanin, D ;

Itin, A ;

Pode, D ;

Keshet, E .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (02) :159-165

[14] Effects of angiogenesis inhibitors on multistage carcinogenesis in mice [J].

Bergers, G ;

Javaherian, K ;

Lo, KM ;

Folkman, J ;

Hanahan, D .

SCIENCE, 1999, 284 (5415) :808-812

[15] Endostatin, an antiangiogenic drug, induces tumor stabilization after chemotherapy or anti-CD20 therapy in a NOD/SCID mouse model of human high-grade non-Hodgkin lymphoma [J].

Bertolini, F ;

Fusetti, L ;

Mancuso, P ;

Gobbi, A ;

Corsini, C ;

Ferrucci, PF ;

Martinelli, G ;

Pruneri, G .

BLOOD, 2000, 96 (01) :282-287

[16] Angiogenic growth factors and endostatin in non-Hodgkin's lymphoma [J].

Bertolini, F ;

Paolucci, M ;

Peccatori, F ;

Cinieri, S ;

Agazzi, A ;

Ferrucci, PF ;

Cocorocchio, E ;

Goldhirsch, A ;

Martinelli, G .

BRITISH JOURNAL OF HAEMATOLOGY, 1999, 106 (02) :504-509

[17] The thin red line: Angiogenesis in normal and malignant hematopoiesis [J].

Bertolini, F ;

Mancuso, P ;

Gobbi, A ;

Pruneri, G .

EXPERIMENTAL HEMATOLOGY, 2000, 28 (09) :993-1000

[18] CD3-INDUCED T-CELL ACTIVATION IN THE BONE-MARROW OF MYELOMA PATIENTS - MAJOR ROLE OF CD4(+) CELLS [J].

BIANCHI, A ;

MONTACCHINI, L ;

BARRAL, P ;

BORRIONE, P ;

ATTISANO, C ;

ORSINI, E ;

BOCCADORO, M ;

PILERI, A ;

MASSAIA, M .

BRITISH JOURNAL OF HAEMATOLOGY, 1995, 90 (03) :625-632

[19] Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance [J].

Boehm, T ;

Folkman, J ;

Browder, T ;

OReilly, MS .

NATURE, 1997, 390 (6658) :404-407

[20] Assessing tumor angiogenesis using macromolecular MR imaging contrast media [J].

Brasch, R ;

Pham, C ;

Shames, D ;

Roberts, T ;

vanDijke, K ;

vanBruggen, N ;

Mann, J ;

Ostrowitzki, S ;

Melnyk, O .

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 1997, 7 (01) :68-74

← 1 2 3 4 5 6 7 8 9 10 →