Molecular basis for vaccine development against the ehrlichial pathogen Anaplasma marginale

被引：97

作者：

Palmer, GH ^{[1
]}

Rurangirwa, FR

Kocan, KM

Brown, WC

机构：

[1] Washington State Univ, Program Vector Borne Dis, Pullman, WA 99164 USA

[2] Oklahoma State Univ, Dept Anat Pathol & Pharmacol, Stillwater, OK 74078 USA

来源：

PARASITOLOGY TODAY | 1999年 / 15卷 / 07期

关键词：

D O I：

10.1016/S0169-4758(99)01469-6

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Anaplasma marginale is a tick-transmitted ehrlichial pathogen causing severe morbidity and mortality in livestock on six continents. Development of safe effective vaccines would be greatly facilitated by identification of the protective immune mechanisms and by understanding how the pathogen evades immune effecters to establish persistent infection. In this article, Guy Palmer and colleagues review recent progress in identifying how defined epitopes induce protective immunity and the role of antigenic variation in these epitopes as a mechanism of persistence.

引用

页码：281 / 286

页数：6

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