Acid-degradable polymers for drug delivery: a decade of innovation

被引：346

作者：

Binauld, Sandra ^{[1
]}

Stenzel, Martina H. ^{[1
]}

机构：

[1] Univ New S Wales, CAMD, Sydney, NSW 2052, Australia

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 21期

基金：

澳大利亚研究理事会;

关键词：

CROSS-LINKED MICELLES; PROTEIN-BASED VACCINES; SENSITIVE COPOLYMER MICELLES; AQUEOUS-SOLUTION PROPERTIES; PH-RESPONSIVE POLYMERS; CONTROLLED-RELEASE; HPMA COPOLYMERS; IN-VITRO; INTRACELLULAR DELIVERY; HYALURONIC-ACID;

D O I：

10.1039/c2cc36589h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polymers that start degrading under acidic conditions are increasingly investigated as a pathway to trigger the release of drugs once the drug carrier reached the slightly acidic tumour environment or after the drug carrier has been taken up by cells, resulting in the localization of the polymer in the acidic endosomes and lysosomes. The advances in the design of acid-degradable polymers and drug delivery systems have been summarized and discussed in this review article. Various acid-labile groups such as acetals, orthoester, hydrazones, imines and cis-aconityl, that can undergo cleavage in slightly acidic conditions, have been employed to create polymer architectures or polymer-drug conjugates that can degrade under lysosomal and endosomal conditions, triggering the fast release of drugs or DNA.

引用

页码：2082 / 2102

页数：21

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