CATH: expanding the horizons of structure-based functional annotations for genome sequences

被引：90

作者：

Sillitoe, Ian ^{[1
]}

Dawson, Natalie ^{[1
]}

Lewis, Tony E. ^{[1
]}

Das, Sayoni ^{[1
]}

Lees, Jonathan G. ^{[1
]}

Ashford, Paul ^{[1
]}

Tolulope, Adeyelu ^{[1
]}

Scholes, Harry M. ^{[1
]}

Senatorov, Ilya ^{[1
]}

Bujan, Andra ^{[1
]}

Rodriguez-Conde, Fatima Ceballos ^{[1
]}

Dowling, Benjamin ^{[1
]}

Thornton, Janet ^{[2
]}

Orengo, Christine A. ^{[1
]}

机构：

[1] UCL, Struct & Mol Biol, London WC1E 6BT, England

[2] European Bioinformat Inst, Wellcome Trust Genome Campus, Hinxton CB10 1SD, Cambs, England

来源：

NUCLEIC ACIDS RESEARCH | 2019年 / 47卷 / D1期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

PROTEIN FUNCTION; LARGE-SCALE; CLASSIFICATION; EVOLUTION; RESOURCE;

D O I：

10.1093/nar/gky1097

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This article provides an update of the latest data and developments within the CATH protein structure classification database (http://www.cathdb.info). The resource provides two levels of release: CATH-B, a daily snapshot of the latest structural domain boundaries and superfamily assignments, and CATH+, which adds layers of derived data, such as predicted sequence domains, functional annotations and functional clustering (known as Functional Families or FunFams). The most recent CATH+ release (version 4.2) provides a huge update in the coverage of structural data. This release increases the number of fully- classified domains by over 40% (from 308 999 to 434 857 structural domains), corresponding to an almost two- fold increase in sequence data (from 53 million to over 95 million predicted domains) organised into 6119 superfamilies. The coverage of high-resolution, protein PDB chains that contain at least one assigned CATH domain is now 90.2% (increased from 82.3% in the previous release). A number of highly requested features have also been implemented in our web pages: allowing the user to view an alignment between their query sequence and a representative FunFam structure and providing tools that make it easier to view the full structural context (multi-domain architecture) of domains and chains.

引用

页码：D280 / D284

页数：5

共 24 条

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