Use of immobilized organic base catalysts for continuous-flow fine chemical synthesis

被引：44

作者：

Soldi, L. ^{[1
]}

Ferstl, W. ^{[2
]}

Loebbecke, S. ^{[2
]}

Maggi, R. ^{[1
]}

Malmassari, C. ^{[1
]}

Sartori, G. ^{[1
]}

Yada, S. ^{[2
]}

机构：

[1] Univ & Consorzio Interuniv Chim Ambiente INCA, Dipartimento Chim Organ & Ind, Clean Synthet Methodol Grp, I-43100 Parma, Italy

[2] Fraunhofer Inst Chem Technol ICT, D-76327 Pfinztal, Germany

来源：

JOURNAL OF CATALYSIS | 2008年 / 258卷 / 02期

关键词：

nitroaldol condensation; Michael addition; heterogeneous catalysis; organic-inorganic hybrid composites; supported catalysts; continuous-flow processes;

D O I：

10.1016/j.jcat.2008.07.005

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A continuous-flow two-step process for the production of multifunctional intermediate compounds was performed with a combination of two column reactors packed with different organic immobilized catalysts. The first step of the reaction, nitroaldol condensation between aromatic aldehydes and nitromethane, is promoted by a silica gel-supported primary amine; the second step, Michael addition of beta-dicarbonyl compounds to the nitrostyrenes obtained in the first step, is catalyzed by a silica gel-supported guanidine TBD. In both cases, the catalysts can be directly reused for several runs with no significant changes in activity. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：289 / 295

页数：7

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