MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway

被引：52

作者：

Li, Nan ^{[1
,2
]}

Tang, Anliu ^{[1
,2
]}

Huang, Shuo ^{[1
]}

Li, Zeng ^{[1
]}

Li, Xiayu ^{[1
,2
]}

Shen, Shourong ^{[1
,2
]}

Ma, Jian ^{[2
,3
,4
,5
]}

Wang, Xiaoyan ^{[1
,2
]}

机构：

[1] Cent S Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Hunan, Peoples R China

[2] Hunan Key Lab Nonresolving Inflammat & Canc, Changsha, Hunan, Peoples R China

[3] Cent S Univ, Canc Res Inst, Changsha, Hunan, Peoples R China

[4] Minist Hlth, Key Lab Carcinogenesis, Changsha, Hunan, Peoples R China

[5] Minist Educ, Key Lab Carcinogenesis & Canc Invas, Changsha, Hunan, Peoples R China

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2013年 / 380卷 / 1-2期

关键词：

MiR-126; Colon cancer; Cancer proliferation; Cancer metastasis; RhoA; RHO-GTPASES; BREAST-CANCER; COLORECTAL-CANCER; MICRORNA; EXPRESSION; METASTASIS; PROGNOSIS; CARCINOMA; MIGRATION; PROFILES;

D O I：

10.1007/s11010-013-1664-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent data strongly suggests the profound role of miRNAs in cancer progression. Here, we showed miR-126 expression was much lower in HCT116, SW620 and HT-29 colon cancer cells with highly metastatic potential and miR-126 downregulation was more frequent in colorectal cancers with metastasis. Restored miR-126 expression inhibited HT-29 cell growth, cell-cycle progression and invasion. Mechanically, microarray results combined with bioinformatic and experimental analysis demonstrated miR-126 exerted cancer suppressor role via inhibiting RhoA/ROCK signaling pathway. These results suggest miR-126 function as a potential tumor suppressor in colon cancer progression and miR-126/RhoA/ROCK may be a novel candidate for developing rational therapeutic strategies.

引用

页码：107 / 119

页数：13

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