Sequential aldol condensation catalyzed by DERA mutant Ser238Asp and a formal total synthesis of atorvastatin

被引：69

作者：

Liu, JJ

Hsu, CC

Wong, CH

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 11期

关键词：

D O I：

10.1016/j.tetlet.2004.01.110

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mutant D-2-deoxyribose-5-phosphate aldolase (DERA), Ser238Asp, was used to prepare P-hydroxy-delta-lactol synthons and a key intermediate for atorvastatin synthesis. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2439 / 2441

页数：3

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