Catalytic enantioselective Conia-ene reaction

被引：178

作者：

Corkey, BK ^{[1
]}

Toste, FD ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 49期

关键词：

D O I：

10.1021/ja055059q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enantioselective intramolecular Conia-ene reaction of β-dicarbonyl compounds and alkynes to afford methylene cyclopentanes is described. The reaction employs a DTBMSegphos-Pd(II)/Yb(III) dual catalyst system that allows for the asymmetric synthesis of all-carbon quaternary centers and generates a product containing an alkene that can be further manipulated. Copyright © 2005 American Chemical Society.

引用

页码：17168 / 17169

页数：2

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