Hydrogen bond template-directed polymerization of protected 5′-acryloylnucleosides

被引：67

作者：

Khan, A ^{[1
]}

Haddleton, DM ^{[1
]}

Hannon, MJ ^{[1
]}

Kukulj, D ^{[1
]}

Marsh, A ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

MACROMOLECULES | 1999年 / 32卷 / 20期

关键词：

D O I：

10.1021/ma990283j

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(5'-acryloyluridine) has been shown to act as a template in the radical polymerization of the complementary 5'-acryloyladenosine in the presence of the noncomplementary 5'-acryloyluridine. The template was synthesized by polymerizing 5'-acryloyluridine using AIBN as the initiator. The 5'-acryloylnucleosides were synthesized by regiospecific acylation of adenosine and uridine at the 5'-position using the enzyme Candida antarctica lipase 435 (CAL 435). The remaining hydroxyl groups were protected as silyl ethers to increase the solubility in nonpolar solvents.

引用

页码：6560 / 6564

页数：5

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