Synthesis of guanosine analogs bearing pendant alkylthiol tethers

被引：18

作者：

Gundlach, CW ^{[1
]}

Ryder, TR ^{[1
]}

Glick, GD ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT CHEM,ANN ARBOR,MI 48109

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 23期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(97)00868-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of three guanosine monomers substituted with alkylthiol chains at either carbon-8 or the 2'-hydroxyI is described. The ready accessibility of these monomers will facilitate the use of disulfide cross-links to study the Folding and dynamics of RNA and will also provide loci for conjugation of reporter groups. (C) 1997 Elsevier Science Ltd.

引用

页码：4039 / 4042

页数：4

共 24 条

[1] SIMPLIFIED AND COST-EFFECTIVE SYNTHESES OF FULLY PROTECTED PHOSPHORAMIDITE MONOMERS SUITABLE FOR THE ASSEMBLY OF OLIGO(2'-O-ALLYLRIBONUCLEOTIDES)
BEIJER, B
GROTLI, M
DOUGLAS, ME
SPROAT, BS
[J]. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1994, 13 (09) : 1905 - 1927
[2] STRUCTURE AND DYNAMICS OF ESCHERICHIA-COLI CHEMOSENSORY RECEPTORS - ENGINEERED SULFHYDRYL STUDIES
CAREAGA, CL
FALKE, JJ
[J]. BIOPHYSICAL JOURNAL, 1992, 62 (01) : 209 - 219
[3] EFFICIENT SYNTHESIS OF 2'-O-ALKYL RIBONUCLEOSIDES USING TRICHLOROACETIMIDATE D-RIBOFURANOSIDES AS RIBOSYL DONORS
CHANTELOUP, L
THUONG, NT
[J]. TETRAHEDRON LETTERS, 1994, 35 (06) : 877 - 880
[4] ENGINEERED DISULFIDE BONDS AS PROBES OF THE FOLDING PATHWAY OF BARNASE - INCREASING THE STABILITY OF PROTEINS AGAINST THE RATE OF DENATURATION
CLARKE, J
FERSHT, AR
[J]. BIOCHEMISTRY, 1993, 32 (16) : 4322 - 4329
[5] AN APPROACH TOWARDS THIOL MEDIATED LABELING IN THE MINOR-GROOVE OF OLIGONUCLEOTIDES
DOUGLAS, ME
BEIJER, B
SPROAT, BS
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (08) : 995 - 1000
[6] Ferentz A.E., 1994, NUCL ACIDS MOL BIOL, V8, P14
[7] REMOVAL OF CYCLIC DI-TERT-BUTYLSILANEDIYL PROTECTING GROUPS USING TRIBUTYLAMINE HYDROFLUORIDE (TBAHF) REAGENT
FURUSAWA, K
[J]. CHEMISTRY LETTERS, 1989, (03) : 509 - 510
[8] Design, synthesis, and analysis of yeast tRNA(Phe) analogs possessing intra- and interhelical disulfide cross-links
Goodwin, JT
Osborne, SE
Scholle, EJ
Glick, GD
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (22) : 5207 - 5215
[9] A simple method for the synthesis of 2'-O-alkylguanosine derivatives
Grotli, M
Douglas, M
Beijer, B
Eritja, R
Sproat, B
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (04) : 425 - 428
[10] THE PARA-NITROPHENYLETHYL (NPE) GROUP - A VERSATILE NEW BLOCKING GROUP FOR PHOSPHATE AND AGLYCONE PROTECTION IN NUCLEOSIDES AND NUCLEOTIDES
HIMMELSBACH, F
SCHULZ, BS
TRICHTINGER, T
CHARUBALA, R
PFLEIDERER, W
[J]. TETRAHEDRON, 1984, 40 (01) : 59 - 72

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