Biocompatibility of silica coated NaYF4 upconversion fluorescent nanocrystals

被引：450

作者：

Jalil, Rufaihah Abdul

Zhang, Yong ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Fac Engn, Div Bioengn, Singapore 117574, Singapore

[2] Natl Univ Singapore, Nanosci & Nanotechnol Initiat, Singapore 117576, Singapore

来源：

BIOMATERIALS | 2008年 / 29卷 / 30期

关键词：

Near infrared; Upconversion nanocrystals; Imaging; Toxicity; Biodistribution;

D O I：

10.1016/j.biomaterials.2008.07.012

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Here we report the synthesis of uniform silica coated hexagonal-phase NaYF4 nanocrystals with Strong NIR-to-visible upconversion fluorescence and its cytotoxicity and biodistribution in a rat model. The silica coated NaYF4 nanocrystals were incubated with rat skeletal myoblasts and bone marrow-derived mesenchymal stem cells and cytotoxicity was assessed by using MTS and LDH assay. Healthy rats were injected intravenously with the nanocrystals so as to further investigate their biocompatibility and tissue distribution. The results from this study revealed that the silica coated NaYF4 upconversion nanocrystals displayed good in vitro and in vivo biocompatibility, demonstrating their potential applications in both cellular and animal imaging systems. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4122 / 4128

页数：7

共 22 条

[21] Design of a highly sensitive and specific nucleotide sensor based on photon upconverting particles [J].