Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase

被引:264
作者
Vogel, Christoph F. A. [1 ,2 ]
Goth, Samuel R. [3 ]
Dong, Bin [1 ]
Pessah, Isaac N. [3 ,4 ]
Matsumura, Fumio [1 ,2 ]
机构
[1] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA
[2] Univ Calif Davis, Ctr Hlth & Environm, Davis, CA 95616 USA
[3] Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616 USA
[4] Univ Calif Davis, Ctr Childrens Environm Hlth, Natl Inst Environm Hlth Sci, Davis, CA 95616 USA
关键词
Ahr; DC-CK1; CD86; Foxp3; IDO; IL-8; TCDD;
D O I
10.1016/j.bbrc.2008.07.156
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
Aryl hydrocarbon receptor (AhR) activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to immune Suppression associated with the induction of regulatory T cells (T-reg) expressing the transcription factor Foxp3. The immunological mechanisms of suppression are not well understood however dendritic cells (DC) are considered a key target for AhR-mediated immune Suppression. Here we show that activation of AhR by TCDD induces DC indoleamine 2,3-dioxygenase 1 (IDO1) and indoleamine 2,3-dioxygenase-like protein (IDO2). Induction of IDO1 and IDO2 was also found in lung and spleen associated with ail increase of the T-reg marker Foxp3 in spleen of TCDD-treated C57BL/6 mice, which is suppressed by inhibition of IDO. These data indicate that AhR-activation is an important signaling pathway for IDO expression and suggest a Critical role of IDO in the mechanism leading to the generation of T-reg that mediates the immune suppression through activation of AhR. (C) 2008 Elsevier Inc. All Fights reserved.
引用
收藏
页码:331 / 335
页数:5
相关论文
共 18 条
[1]
Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice [J].
Ball, Helen J. ;
Sanchez-Perez, Angeles ;
Weiser, Silvia ;
Austin, Christopher J. D. ;
Astelbauer, Florian ;
Miu, Jenny ;
McQuillan, James A. ;
Stocker, Roland ;
Jermiin, Lars S. ;
Hunt, Nicholas H. .
GENE, 2007, 396 (01) :203-213
[2]
Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation [J].
Fritsche, Ellen ;
Schaefer, Claudia ;
Calles, Christian ;
Bernsmann, Thorsten ;
Bernshausen, Thorsten ;
Wurm, Melanie ;
Huebenthal, Ulrike ;
Cline, Jason E. ;
Hajimiragha, Hossein ;
Schroeder, Peter ;
Klotz, Lars-Oliver ;
Rannug, Agneta ;
Fuerst, Peter ;
Hanenberg, Helmut ;
Abel, Josef ;
Krutmann, Jean .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (21) :8851-8856
[3]
Cutting edge:: Activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4+CD25+ cells with characteristics of regulatory T cells [J].
Funatake, CJ ;
Marshall, NB ;
Steppan, LB ;
Mourich, DV ;
Kerkvliet, NI .
JOURNAL OF IMMUNOLOGY, 2005, 175 (07) :4184-4188
[4]
HAUBEN E, 2008, BLOOD
[5]
Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses [J].
Hou, De-Yan ;
Muller, Alexander J. ;
Sharma, Madhav D. ;
DuHadaway, James ;
Banerjee, Tinku ;
Johnson, Maribeth ;
Mellor, Andrew L. ;
Prendergasts, George C. ;
Munn, David H. .
CANCER RESEARCH, 2007, 67 (02) :792-801
[6]
Recent advances in understanding the mechanisms of TCDD immunotoxicity [J].
Kerkvliet, NI .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2002, 2 (2-3) :277-291
[7]
Induction of immunosuppressive functions of dendritic cells in vivo by CD4+CD25+ regulatory T cells:: Role of B7-H3 expression and antigen presentation [J].
Mahnke, Karsten ;
Ring, Sabine ;
Johnson, Theron S. ;
Schallenberg, Sonja ;
Schoenfeld, Kurt ;
Storn, Volker ;
Bedke, Tanja ;
Enk, Alexander H. .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (08) :2117-2126
[8]
IDO expression by dendritic cells: Tolerance and tryptophan catabolism [J].
Mellor, AL ;
Munn, DH .
NATURE REVIEWS IMMUNOLOGY, 2004, 4 (10) :762-774
[9]
Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase [J].
Munn, DH ;
Sharma, MD ;
Lee, JR ;
Jhaver, KG ;
Johnson, TS ;
Keskin, DB ;
Marshall, B ;
Chandler, P ;
Antonia, SJ ;
Burgess, R ;
Slingluff, CL ;
Mellor, AL .
SCIENCE, 2002, 297 (5588) :1867-1870
[10]
Prevention of allogeneic fetal rejection by tryptophan catabolism [J].
Munn, DH ;
Zhou, M ;
Attwood, JT ;
Bondarev, I ;
Conway, SJ ;
Marshall, B ;
Brown, C ;
Mellor, AL .
SCIENCE, 1998, 281 (5380) :1191-1193