Non-coding RNAs with essential roles in neurodegenerative disorders

被引：217

作者：

Salta, Evgenia ^{[1
,2
,3
]}

De Strooper, Bart ^{[1
,2
,3
]}

机构：

[1] VIB Ctr Biol Dis VIB11, B-3000 Louvain, Belgium

[2] Univ Leuven, Ctr Human Genet, Louvain, Belgium

[3] Univ Leuven, Leuven Inst Neurodegenerat Disorders LIND, Louvain, Belgium

来源：

LANCET NEUROLOGY | 2012年 / 11卷 / 02期

基金：

欧洲研究理事会;

关键词：

NATURAL ANTISENSE TRANSCRIPTS; CENTRAL-NERVOUS-SYSTEM; MICRORNA TARGET SITES; TERM-MEMORY FORMATION; ALZHEIMERS-DISEASE; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE; GENE-EXPRESSION; BINDING-SITE; PERVASIVE TRANSCRIPTION;

D O I：

10.1016/S1474-4422(11)70286-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The importance of various classes of regulatory non-protein-coding RNA molecules (ncRNAs) in the normal functioning of the CNS is becoming increasingly evident. ncRNAs are involved in neuronal cell specification and patterning during development, but also in higher cognitive processes, such as structural plasticity and memory formation in the adult brain. We discuss advances in understanding of the function of ncRNAs in the CNS, with a focus on the potential involvement of specific species, such as microRNAs, endogenous small interfering RNAs, long intergenic non-coding RNAs, and natural antisense transcripts, in various neurodegenerative disorders. This emerging field is anticipated to profoundly affect clinical research, diagnosis, and therapy in neurology.

引用

页码：189 / 200

页数：12

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