Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis

被引：22

作者：

Barn, DR ^{[1
]}

Bom, A ^{[1
]}

Cottney, J ^{[1
]}

Caulfield, WL ^{[1
]}

Morphy, JR ^{[1
]}

机构：

[1] Organon Labs Ltd, Newhouse ML1 5SH, Scotland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(99)00174-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two focused libraries of delta opioid ligands were synthesised using AlCl3 facilitated aminolysis. Several compounds were identified with DOR binding affinities higher or similar to SNC-IO. A novel acyclic derivative of SNC-80 produced antinociception in the acetic acid abdominal constriction test, which is at least partially mediated via the delta-opioid receptor. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1329 / 1334

页数：6

共 7 条

[1] Synthesis of an array of amides by aluminium chloride assisted cleavage of resin-bound esters [J].