Interlaboratory comparison of size measurements on nanoparticles using nanoparticle tracking analysis (NTA)

被引：168

作者：

Hole, Patrick ^{[1
]}

Sillence, Katherine ^{[1
]}

Hannell, Claire ^{[1
]}

Maguire, Ciaran Manus ^{[2
]}

Roesslein, Matthias ^{[3
]}

Suarez, Guillaume ^{[4
]}

Capracotta, Sonja ^{[5
]}

Magdolenova, Zuzana ^{[6
]}

Horev-Azaria, Limor ^{[7
]}

Dybowska, Agnieszka ^{[8
]}

Cooke, Laura ^{[9
]}

Haase, Andrea ^{[10
]}

Contal, Servane ^{[11
]}

Mano, Stein ^{[6
]}

Vennemann, Antje ^{[12
]}

Sauvain, Jeans-Jacques ^{[4
]}

Staunton, Kieran Crosbie ^{[2
]}

Anguissola, Sergio ^{[9
]}

Luch, Andreas ^{[10
]}

Dusinska, Maria ^{[6
]}

Korenstein, Rafi ^{[7
]}

Gutleb, Arno C. ^{[11
]}

Wiemann, Martin ^{[12
]}

Prina-Mello, Adriele ^{[2
]}

Riediker, Michael ^{[4
]}

Wick, Peter ^{[3
]}

机构：

[1] NanoSight Ltd, Amesbury SP4 7RT, Wilts, England

[2] St James Hosp, Trinity Ctr Hlth Sci, Inst Mol Med, Dept Clin Med, Dublin 8, Ireland

[3] Swiss Fed Labs Mat Res & Testing Empa, Lab Mat Biol Interact, CH-9014 St Gallen, Switzerland

[4] Inst Work & Hlth, CH-1066 Epalinges, Switzerland

[5] NanoSight USA, Ann Arbor, MI 48109 USA

[6] Norwegian Inst Air Res, Dept Environm Chem, Hlth Effects Lab, NO-2027 Kjeller, Norway

[7] Tel Aviv Univ, Sackler Sch Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel

[8] Nat Hist Museum, Dept Earth Sci, London SW7 5BD, England

[9] Univ Coll Dublin, CBNI, Dublin 4, Ireland

[10] BfR, Dept Prod Safety, D-10589 Berlin, Germany

[11] Ctr Rech Publ Gabriel Lippmann, Dept Environm & Agrobiotechnol EVA, L-4422 Belvaux, Luxembourg

[12] Inst Lung Hlth gGmbH, IBE R&D, D-48149 Munster, Germany

来源：

JOURNAL OF NANOPARTICLE RESEARCH | 2013年 / 15卷 / 12期

关键词：

Nanoparticle; Interlaboratory comparison; Reproducibility; Polydispersity; Toxicology; Health and safety implications; DRUG-DELIVERY; IN-VITRO; PROTEINS;

D O I：

10.1007/s11051-013-2101-8

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

One of the key challenges in the field of nanoparticle (NP) analysis is in producing reliable and reproducible characterisation data for nanomaterials. This study looks at the reproducibility using a relatively new, but rapidly adopted, technique, Nanoparticle Tracking Analysis (NTA) on a range of particle sizes and materials in several different media. It describes the protocol development and presents both the data and analysis of results obtained from 12 laboratories, mostly based in Europe, who are primarily QualityNano members. QualityNano is an EU FP7 funded Research Infrastructure that integrates 28 European analytical and experimental facilities in nanotechnology, medicine and natural sciences with the goal of developing and implementing best practice and quality in all aspects of nanosafety assessment. This study looks at both the development of the protocol and how this leads to highly reproducible results amongst participants. In this study, the parameter being measured is the modal particle size.

引用

页数：12

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