The wanderings of a free radical

被引：347

作者：

Halliwell, Barry ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Biochem, 21 Lower Kent Ridge Rd, Singapore 119077, Singapore

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2009年 / 46卷 / 05期

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

Antioxidant; Atherosclerosis; Biomarkers; Cell culture; Coffee; Fenton reaction; Flavonoids; Free radical; Gastrointestinal tract; Iron; Hydrogen peroxide; Hydroxyl radical; Isoprostanes; Photorespiration; Pro-oxidant; Zinc; OXIDATIVE DNA-DAMAGE; TOTAL ANTIOXIDANT CAPACITY; TRANSFERRIN-BOUND IRON; LIPID-PEROXIDATION; HYDROGEN-PEROXIDE; REACTIVE OXYGEN; NITRIC-OXIDE; CELL-CULTURE; IN-VIVO; HYDROXYL RADICALS;

D O I：

10.1016/j.freeradbiomed.2008.11.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In my career I have moved from chemistry to biochemistry to plant science to clinical chemistry and back again (in a partial way) to plants. This review presents a brief history of my research achievements (ascorbate-glutathione cycle, role of iron in oxidative damage and human disease, biomarkers of free radical damage, and studies on atherosclerosis and neurodegeneration) and how they relate to my research activities today. The field of free radicals/other reactive species/antioxidants underpins all of modern Biology. These agents helped to drive human evolution and the basic principles of the field are repeatedly found to be relevant in other research areas. It was an exciting field when I started some 40 years ago, and it still is today, but some major challenges must be faced. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：531 / 542

页数：12

共 239 条

[11] Determinants of intestinal detoxication of lipid hydroperoxides [J].

Aw, TY .

FREE RADICAL RESEARCH, 1998, 28 (06) :637-646

[12] Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential - A workshop report and consensus statement [J].

Ayres, Jon G. ;

Borm, Paul ;

Cassee, Flemming R. ;

Castranova, Vincent ;

Donaldson, Ken ;

Ghio, Andy ;

Harrison, Roy M. ;

Hider, Robert ;

Kelly, Frank ;

Kooter, Ingeborg M. ;

Marano, Francelyne ;

Maynard, Robert L. ;

Mudway, Ian ;

Nel, Andre ;

Sioutas, Constantinos ;

Smith, Steve ;

Baeza-Squiban, Armelle ;

Cho, Art ;

Duggan, Sean ;

Froines, John .

INHALATION TOXICOLOGY, 2008, 20 (01) :75-99

[13]

Baeuerle PA, 1996, PATHOL BIOL, V44, P29

[14] Temporal gene expression analysis of monolayer cultured rat hepatocytes [J].

Baker, TK ;

Carfagna, MA ;

Gao, H ;

Dow, ER ;

Li, QQ ;

Searfoss, GH ;

Ryan, TP .

CHEMICAL RESEARCH IN TOXICOLOGY, 2001, 14 (09) :1218-1231

[15]

Baldus S, 2001, J CLIN INVEST, V108, P1759

[16] Heme, heme oxygenase, and ferritin: How the vascular endothelium survives (and dies) in an iron-rich environment [J].

Balla, Jozsef ;

Vercellotti, Gregory M. ;

Jeney, Viktoria ;

Yachie, Akihiro ;

Varga, Zsuzsa ;

Jacob, Harry S. ;

Eaton, John W. ;

Balla, Gyoergy .

ANTIOXIDANTS & REDOX SIGNALING, 2007, 9 (12) :2119-2137

[17] Total antioxidant capacity [J].

Bartosz, G .

ADVANCES IN CLINICAL CHEMISTRY, VOL 37, 2003, 37 :219-292

[18] Oxidative stress and lipid peroxidation-derived DNA-lesions in inflammation driven carcinogenesis [J].

Bartsch, H ;

Nair, J .

CANCER DETECTION AND PREVENTION, 2004, 28 (06) :385-391

[19] Oxidative damage and tyrosine nitration from peroxynitrite [J].

Beckman, JS .

CHEMICAL RESEARCH IN TOXICOLOGY, 1996, 9 (05) :836-844

[20] Endogenous oxidative damage of mtDNA [J].

Beckman, KB ;

Ames, BN .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1999, 424 (1-2) :51-58

← 1 2 3 4 5 6 7 8 9 10 →